Acute Coronary Syndrome STEMI NSTEMI multivessel disease with at least one non-culprit lesion Acute Coronary Syndrome STEMI NSTEMI multivessel disease with at least one non-culprit lesion
Conditions
Interventions
Patients receiving QFR-based deferring revascularization,Patients receiving angiography-based deferring revascularization
Prevention,Prevention
Group 1,Group 2
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with diagnosis of acute coronary syndrome (STEMI or NSTEMI) 2. Presence of multivessel disease with at least one non-culprit lesion (NCLs) at least 2.25 mm in diameter from visual estimation with a diameter stenosis ranging from 50% to 99% amenable to successful treatment with PCI and 3. Successful treatment of culprit lesion
Exclusion criteria
Exclusion criteria: 1. Planned surgical revascularization or valve surgery 2. Prior coronary artery bypass graft surgery 3. Left main lesion as the non-culprit lesion 4. Other concomitant disease precluding 1-year follow-up i.e sepsis, cardiogenic shock that required mechanical circulatory support or required high-dose vasopressor/inotropic agents 5. Prior stent at non-culprit lesions 6. Aorto-ostial lesions 7. At least one chronic total occlusion of NCLs 8. Angiography images were not suitable for QFR analysis: absence of 2 projections with an angle equal or more than 25 degree apart; lack of isocenter calibration; substantial vessel overlap or vessel foreshortening; severe tortuosity; poor contrast; TIMI flow equal or less than 2 9. Being assessed with pressure-wire based
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac Death 2 year Number of Cardiac Death,Spontaneous Nontarget Vessel Myocardial Infarction 2 year Number of Spontaneous Nontarget Vessel Myocardial Infarction,Clinically Indicated Nontarget Vessel Revascularization 2 year Number of Clinically Indicated Nontarget Vessel Revascularization | — |
Secondary
| Measure | Time frame |
|---|---|
| Cut-off value for Deferral Revascularization in Non-Culprit Lesions 2 year Number of Cut-off value,quantitative flow ratio disease pattern in Non-Culprit Lesions 2 year Number of quantitative flow ratio,Any revascularization 2 year Number of procedure ,Any clinical outcomes 2 year Number of Events,Any spontaneous Myocardial Infarction 2 year Number of Events | — |
Countries
Thailand
Contacts
Public ContactPannipa Suwannasom
Faculty of Medicine, Chiang Mai University
Outcome results
None listed