Prevalence of Obstructive Sleep Apnea and Screening Questionnaire Performance in Highly Drug-Resistant Epilepsy

Prevalence of Obstructive Sleep Apnea and Diagnostic Accuracy of Screening Questionnaires in Patients with Highly Drug-Resistant Epilepsy: A Cross-sectional Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20250506008

Enrollment

Registered

2025-05-06

Start date

2024-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea Drug-Resistant Epilepsy Highly Drug-Resistant Epilepsy Sleep Apnea Obstructive Epilepsy Epilepsy Drug-Resistant Screening Polysomnography Questionnaire Diagnosis Prevalence Sensitivity and Specificity ROC Curve

Interventions

Patients aged 18 years or older diagnosed with highly drug-resistant epilepsy (HDRE), undergoing screening with STOP-BANG, SA-SDQ, NoSAS, Berlin Questionnaire, and NH-OSA, followed by in-laboratory ov

Diagnostic

High drug resistant epilepsy patients cohort

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Age 18 years or older 2. Diagnosis of highly drug-resistant epilepsy (HDRE), defined as persistent seizures despite the use of three or more appropriately chosen and tolerated antiepileptic drugs (AEDs) 3. Ability to complete screening questionnaires and undergo overnight polysomnography (PSG) 4. Willingness to provide informed consent

Exclusion criteria

Exclusion criteria: 1. Prior diagnosis of obstructive sleep apnea (OSA) 2. History of undergoing polysomnography (PSG) within the past 5 years 3. Presence of severe uncontrolled systemic illness or psychiatric disorder interfering with study participation

Design outcomes

Primary

Measure	Time frame
Prevalence of obstructive sleep apnea (OSA) At completion of overnight PSG Diagnosis of OSA based on apnea hypopnea index (AHI) greater than or equal to 5 events per hour obtained by overnight in-laboratory polysomnography (PSG)	—

Secondary

Measure	Time frame
Sensitivity and specificity of STOP-BANG questionnaire At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Sensitivity and specificity of SA-SDQ questionnaire At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Sensitivity and specificity of NoSAS score At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Sensitivity and specificity of Berlin Questionnaire At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Sensitivity and specificity of NH-OSA score At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Area under the receiver operating characteristic curve (AUC) for each screening tool At completion of overnight PSG AUC value derived from comparison of each screening questionnaire to the diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG	—

Measure

Time frame

Sensitivity and specificity of STOP-BANG questionnaire At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Sensitivity and specificity of SA-SDQ questionnaire At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Sensitivity and specificity of NoSAS score At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Sensitivity and specificity of Berlin Questionnaire At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Sensitivity and specificity of NH-OSA score At completion of overnight PSG Sensitivity and specificity compared to diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG,Area under the receiver operating characteristic curve (AUC) for each screening tool At completion of overnight PSG AUC value derived from comparison of each screening questionnaire to the diagnosis of OSA (AHI greater than or equal to 5 events per hour) by overnight in-laboratory PSG

—

Countries

Thailand

Contacts

Public ContactSirincha Pitipanyakul

Faculty of Medicine, Chulalongkorn University

meijineuro@gmail.com022564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026