Emergence agitation (EA) is a common postoperative complication after sevoflurane anesthesia, which may lead to wound dehiscence and pulmonary complications that might result in delayed recovery and a prolonged hospital stay. EA is defined as psychomotor agitation and delirium that typically occurs within 45 min from emergence of anesthesia. In cleft palate surgery, incidence of emergence agitation in children receiving sevoflurane anesthesia is high (76-85%). Emergence agitation, cleft palate,
Conditions
Interventions
Group propofol will receive propofol 1 mg/kg at the end of operation.,Group saline will receive normal saline with equivalent volume to propofol group at the end of operation.
Active Comparator Drug,No Intervention No treatment
Propofol group,Saline group
Sponsors
Research Affairs, Faculty of Medicine, KKU
Eligibility
Sex/Gender
All
Age
8 Months to 6 Years
Inclusion criteria
Inclusion criteria: 1. ASA classification 1-2, 2. Scheduled for elective palatoplasty and/or other surgeries, such as cheiloplasty, myringotomy, etc., under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Parent refusal, 2. History of allergy to propofol, egg and other drugs in the study, 3. Neurological disorder or psychological disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emergence agitation On arrival at PACU and then every 15 minutes until 60 minutes Pediatric Anesthesia Emergence Delirium score | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of emergence agitation On arrival at PACU and then every 15 minutes until 60 minutes Pediatric Anesthesia Emergence Delirium score,Postoperative pain On arrival at PACU and then every 15 minutes until 60 minutes Face, Legs, Activity, Cry, Consolability score,Postoperative nausea and vomiting (PONV) at PACU The events of nausea and vomiting,Incidence of hypotension every 2 minutes after intervention given until 10 min then every 15 minutes Blood pressure,Incidence of bradycardia every 2 minutes after intervention given until 10 min then every 15 minutes Heart rate,Incidence of oxygen desaturation every 2 minutes after intervention given until 10 min then every 15 minutes Oxygen saturation,Time of extubation From discontinuing sevoflurane to extubation Time,PACU discharge time From PACU arrival to PACU discharge Time,Parents' satisfaction Before discharge from PACU Numerical rating scale from 1-5 | — |
Countries
Thailand
Contacts
Public ContactPrathana Wittayapairoch
Srinagarind hospital
Outcome results
None listed