patients with ST-elevation myocardial infarction (STEMI). Consecutive patients with STEMI who undergo primary PCI (PPCI) for their culprit-lesions with or without additional PCI for non-culprit lesions, will be randomized after diagnostic coronary angiography (CAG). ST-elevation myocardial infarction (STEMI) Primary percutaneous coronary intervention (PCI) culprit-lesions non-culprit lesions coronary angiography (CAG) Angiography-derived index of microcirculatory resistance (angio-IMR) Intravas
Conditions
Interventions
Intravascular Ultrasound (IVUS) has become a key modality for assessing coronary lesions and guiding PCI by providing detailed anatomical insights. IVUS plays an essential role in morphological assess
Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery
Intravascular ultrasound (IVUS),Near-Infrared Spectroscopy Intravascular Ultrasound Imaging (NIRS-IVUS)
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diagnosis of STEMI and able to receive PPCI within 12 hours after the onset of symptoms. 2. Coronary angiography shows occluded or reduced flow or obstructive coronary artery stenosis > 50% with evidence of thrombus at culprit artery
Exclusion criteria
Exclusion criteria: 1. severe hemodynamic disturbance before PCI (cardiogenic shock SCAI stage equal or more than D, need for intra-aortic balloon pump, malignant arrhythmia) 2. Life expectancy less than 1 year 3. Bypass graft or stent thrombosis or in stent restenosis lesion 4. Pregnancy 5. Contraindications to heparin or antiplatelet therapy 6. Severe tortuous, or angulated coronary anatomy of the study vessel that in the opinion of the investigator would result in suboptimal imaging or excessive risk of complication from placement of an imaging catheter 7. Inadequate image quality for angio-IMR computation (poor image quality, excessive vessel overlap)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Angiography-derived index of microcirculatory resistance (angio-IMR) 2 weeks, 6 weeks, 3 months, 6 months, and 12 months Angiography-derived index of microcirculatory resistance value | — |
Secondary
| Measure | Time frame |
|---|---|
| major adverse cardiac events (MACE) 1 year Number of Event,individual endpoint of major adverse cardiac 1 year Number of individual event,patient-oriented composite endpoint (POCE) 1 year Number of event | — |
Countries
Thailand
Contacts
Public ContactPannipa Suwannasom
Faculty of Medicine, Chiang Mai University
Outcome results
None listed