Patient with hepatocellular carcinoma Chain Fatty Acids, Feces, Hepatocellular Carcinoma, Acetic Acid, Propionic Acid, Butyric Acid
Conditions
Interventions
Participants aged 18 years or older with newly diagnosed advanced-stage hepatocellular carcinoma (HCC) confirmed diagnosis with CT or MRI.,Healthy individuals residing in Northeastern Thailand, Parti
Other,Other
Hepatocellular Carcinoma Patients,Healthy Controls
Sponsors
Faculty of Medicine, KhonKaen university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed patients with advanced-stage hepatocellular carcinoma aged 18 years or older 1. No history of other cancers, or has been cancer-free for more than 5 years 1. Originally from and currently residing in Northeastern Thailand
Exclusion criteria
Exclusion criteria: 1. Patients diagnosed with combined hepatocellular-cholangiocarcinoma (cHCC-CCA) 2 Use of medications or products that affect gut microbiota within 14 days, such as antibiotics, proton pump inhibitors, probiotics, or ursodeoxycholic acid 3. Individuals with specific dietary behaviors, such as strict vegetarianism, veganism, or intermittent fasting 4. Inability to collect stool samples or provide adequate sample volume for analysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| compare the fecal concentrations of acetic, propionic, and butyric acids At time of study enrollment measure by nuclear magnetic resonance (NMR) spectroscopy-based metabolomics. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the association between fecal SCFA levels and prognostic factors in HCC patients. At time of study enrollment measure by nuclear magnetic resonance (NMR) spectroscopy-based metabolomics. | — |
Countries
Thailand
Contacts
Public ContactTheeradon Kitsahawong
Faculty of Medicine, Khonkaen Univesity
Outcome results
None listed