Oral glucose tolerance test to predict intraoperative hyperglycemia in neurosurgical patient Stress induce hyperglycemia Elective neurosurgical patient Oral glucose tolerance test Impair fasting blood glucose Impair glucose tolerance test Normal glucose tolerance test
Conditions
Interventions
Patients undergoing elective neurosurgery with a preoperative 2-hour post 75g- OGTT glucose level less than 140 mg/dL. ,Patients undergoing elective neurosurgery with a preoperative 2-hour post 75g-
Diagnostic,Diagnostic
Normal glucose tolerance test,Impair glucose tolerance test
Sponsors
Department of Anesthesiology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Written informed consent obtained from the patients I appreciate participating in this study with the sign 2. Age 18 - 80 years old 3.Neurosurgical patient undergo elective neurosurgical procedure with general anesthesia technique 4. Patient who has blood HbA1c level < 6.5 % with in 3 months before operation
Exclusion criteria
Exclusion criteria: 1. Patients who diagnosed diabetic melitus 2. Preexisting CKD stage 5 3.Patients at increased risk for aspiration include those with obesity patients BMI > 35 kg/m2, pregnancy, achalacia, stomach and esophageal cancer, GERD 4.neurological disorders include conditions that affect the gag reflex or esophageal motility 5.Patients who has CN IX,X,XII impairment 6.Patients who has local and systemic infection 7.Patients who receive intravenous dextrose before induction 8.Patient with altered mental status ( GCS < 15 ) or impaired cognitive fucntion ( from 6 questions cognitive fuction test in Thai language ) 9.FBS > 126 mg/dL 10.HbA1c 6.5 or more than 6.5% within 3 months before operation 11.Patients who have BS more than 200 mg/dL after 75g Oral glucose tolerance test ( diagnosed DM)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity of preoperative 75g-OGTT to predict intraoperative hyperglycemia End of surgery Calculation of sensitivity base on preoperative OGTT classification and the occurrence of intraoperative hyperglycemia. Data collected via pre-op blood tests and hourly intraoperative POC- glucose. | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of intraoperative hyperglycemia on surgical outcomes. post operative period at hospital discharge, 30 days post operation. Comparison of postoperative outcomes between patient who developed intraoperative hyperglycemia and who did not, using appropiate statistical analyses . | — |
Countries
Thailand
Contacts
Public ContactKulawat Jirapaet
Department of Anesthesiology Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed