Patients with persistent allergic rhinitis Allergic rhinits, intranasal corticosteroid
Conditions
Interventions
MP-AzeFlu nasal spray, 2 sprays per nostril twice daily (morning and evening), with the option to use up to 4 additional sprays per day as needed for symptom relief.,MP-AzeFlu nasal spray, 1 spray per
Experimental Drug,Experimental Drug
Increased dosage of Mp-AzeFlu,Standard dosage of MP-AzeFlu
Sponsors
Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Allergic rhinitis patients following diagnostic criteria of ARIA guideline14 2. Age >= 18 years 3. Visual Analog Scale (VAS) score >= 5, with persistent symptoms (greater than 4 weeks) 4. Not currently using intranasal corticosteroid for 2 weeks, systemic corticosteroid for four weeks, oral antihistamine for one week, nasal decongestant for one week, and leukotriene receptor antagonists for one week. 5. Diagnosis of AR was confirmed by skin prick test. Seven common allergens in Thailand were tested for sensitization, comprising Dermatophagoides farinae, Dermatophagoides pteronyssinus, cockroach, dog hair, cat hair, careless weed, and paragrass (AllerVACtest10, Greater Pharma, Bangkok, Thailand).
Exclusion criteria
Exclusion criteria: 1. Diagnosis of acute or chronic rhinosinusitis 2. AR and asthma requiring immunotherapy 3. Neoplasm of nasal and sinus mucosa 4. Previous surgery for nasal polyp or nasal septum deviation 5. Pregnancy and lactation 6. Refusal to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptom improvement Assessed daily over 7 days Visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptom improvement Assessed daily over 7 days Total nasal symptom score, itchy eye symtpom | — |
Countries
Thailand
Contacts
Public ContactSasicha Siriprapanukul
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed