Pain on movement in patient with knee osteoarthritis measure by Visual analog scale(VAS ) score knee osteoarthritis , pain , Visual analog scale(VAS ) score
Conditions
Interventions
Hyaluronic acid single dose with Diacerein for 3 months,Hyaluronic acid injection single dose with placebo for 3 months
Experimental Drug,Placebo Comparator Drug
Sponsors
Orthopedics department, Faculty of Medicine Siriraj Hospital, Mahidol Universit
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1 Patients with primary OA knee based on clinical criteria of ACR 2 Patients have been experiencing knee pain due to OA knee for over 3 months 3 Kellgren and Lawrence (KL) grade 2-3
Exclusion criteria
Exclusion criteria: 1 Planned Knee replacement surgery 2 Previous oral SYSADOA within 3 months 3 Previous intra-articular knee injections within 6 months 4 Inflammatory arthritis (rheumatoid arthritis , systemic lupus erythematosus ) 5 Known allergy to hyaluronan products , diacerein
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain on movement 12 weeks Visual analog scale(VAS ) score | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain on movement 6 , 12 , 18 , 24 weeks Visual analog scale(VAS ) score,WOMAC score 6 , 12 , 18 , 24 weeks WOMAC score is a widely used instrument for assessing the impact of osteoporosis arthritis on patients in 3 domain 1.pain(5 questions) 2.stiffness(2questions) 3.physical function(15 questions) ,Rescue medication usage 6 , 12 , 18 , 24 weeks Paracetamol and Ibuprofen | — |
Countries
Thailand
Contacts
Public ContactRapeepat Narkbunnam
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed