Postoperative delirium in elderly patients undergoing orthopedic surgery Postoperative delirium, elderly, orthopedic
Conditions
Interventions
Participants in this group will receive 2 mg of melatonin administered orally as a tablet once daily at bedtime for 5 consecutive nights. The first dose will be given the night before surgery (D-1) an
Experimental Drug,Experimental Drug
Low-dose Melatonin (2 mg),High-Dose Melatonin (6 mg)
Sponsors
Pranangklao Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age > 65 years 2. Undergoing non-emergency orthopedic surgery 3. ASA physical status I-III 4. Expected hospital stay > 72 hours postoperatively 5. Able to provide informed consent
Exclusion criteria
Exclusion criteria: 1. Pre-existing cognitive impairment (e.g. diagnosed dementia, Alzheimer disease) 2. Chronic melatonin use or history of sleep disorders 3. Severe hepatic impairment 4. Severe renal impairment 5. History of allergy to melatonin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium 5 days postoperative Confusion Assessment Method (CAM) | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality 5 days postoperative Richards-Campbell sleep questionnaire,Length of hospital stay Hospital discharge Day,Melatonin side effects 5 days postoperative Assessor daily visit | — |
Countries
Thailand
Contacts
Public ContactPornchanan Duriyaprapan
Pranangklao Hospital
Outcome results
None listed