Atrophic acne scar Atrophic acne scar, atrophic scar, depressed acne acar, depressed scar, acne scar, picosecond laser, fractional picosecond laser, hydrodissection
Conditions
Interventions
Hydrodissection, followed by treatment with a fractional picosecond laser (energy 8 J/cm2, frequency 10 Hz, spot size 8 mm), will be performed on the atrophic scars on one side of the cheek, as determ
Experimental Procedure/Surgery,Experimental Device
Hydrodissection prior fractional picosecond laser,Fractional picosecond laser alone
Sponsors
Strategic Wisdom and Research Institute
Roche Thailand
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older, 2. Fitzpatrick skin type III-IV, 3. Presence of atrophic acne scars on both cheeks with similar severity, classified as grade 3 or higher according to the Goodman and Baron grading scale, including well-defined deep scars less than 5 mm in diameter, scars extending into the reticular dermis, or broad deep atrophic scars, 4. Willingness to participate in the study voluntarily, with written informed consent provided by signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals who have undergone treatment with either ablative or non-ablative lasers within the past 3 months, 2. Individuals who have received dermabrasion, microdermabrasion, or subcision in the study area within the past 1 month, 3. Individuals who have undergone dermal filler injections, including collagen, silicone, hyaluronic acid, autologous fat implants, or other substances deemed relevant by the investigators, in the study area within the past 12 months, 4. Individuals who have received chemical peeling treatments, such as glycolic acid, Jessners solution, pyruvic acid, salicylic acid, trichloroacetic acid, or phenol, in the study area within the past 1 month, 5. Individuals currently using topical retinoids, such as tretinoin or adapalene, within the past 1 month, 6. Individuals who have received corticosteroids via oral, injectable, or topical routes within the past 1 month, 7. Individuals with a history of oral isotretinoin use within the past 6 months, 8. Individuals taking hormonal therapy or oral contraceptives within the past 1 month, 9. Individuals using anticoagulants or antiplatelet medications within the past 1 month, 10. Individuals with active acne in the study area, 11. Individuals with active or recurrent herpes simplex infections or bacterial infections in the study area at the time of screening or study initiation, 12. Individuals with inflammatory skin conditions in the study area, 13. Individuals with a history of hypertrophic scars or keloids, 14. Individuals with a known allergy to topical or injectable local anesthetics, 15. Pregnant or breastfeeding individuals, 16. Individuals with immunodeficiency disorders or those undergoing immunosuppressive therapy, chemotherapy, or radiation therapy, 17. Individuals with systemic conditions affecting wound healing and scar formation, such as Ehlers-Danlos syndrome, Marfan syndrome, hemophilia, Cushings syndrome, hyperthyroidism, or other conditions deemed relevant by the investigators., 18. Individuals with dermatological conditions associated with the Koebner phenomenon, such as psoriasis, vitiligo, lichen planus, or lichen nitidus., 19. Individuals unable to comply with follow-up visits throughout the study duration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| scar volume baseline, week 4, 8, 12, 16, and 20 after treatment Antera 3D,Improvement of scar by two dermatologists Week 4, 8, 12, 16, and 20 after treatment Quartile grading scale,Satisfaction of atrophic acne scar treatment End of the treatment (week 20 after treatment) 5-scores rating scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects (e.g. erythema, bruise, crusting, burns, post inflammatory hyperpigmentation, post inflammatory hypopigmentation immediate after treatment and week 4, 8, 12, 16, and 20 after treatment Assessment by physician, Patient report | — |
Countries
Thailand
Contacts
Public ContactPintusorn Kungvalpivat
Department of Dermatology, Faculty of Medicine, Srinakharinwirot University
Outcome results
None listed