VExUS and LUS score change in critically ill patients with fluid overload undergoing fluid removal therapy fluid overload
Conditions
Interventions
Adult patients aged 18 years old or older who admitted to the medical intensive care unit and required fluid removal
Diagnostic
Critical ills with fluid overload
Sponsors
Faculty of Medicine Siriraj Hospital , Mahidol University ,Thailand
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Adult patients aged 18 years old or older who admitted to the medical intensive care unit and are expected to remain in the ICU for over 120 hours. 2) The patient had stable vital signs without the need for rapid fluid resuscitation (at least 500 milliliters of colloid or 1000 milliliters of crystalloid) or with minimal vasoactive medications (e.g., norepinephrine at a rate not exceeding 0.1 micrograms per kilogram per minute and dobutamine at a rate not exceeding 10 micrograms per kilogram per minute) for a consecutive period of 12 hours. 3) The patients require fluid removal determined by the attending physicians and involved the use of either diuretics or renal replacement therapy.
Exclusion criteria
Exclusion criteria: 1) Underlying chronic kidney disease stage 4 or higher, or those undergoing chronic dialysis, such as intermittent hemodialysis or peritoneal dialysis 2) Decompensated cirrhosis with portal hypertension 3) History of IVC, PV, HV, or renal vein thrombosis 4) Ureteral obstruction 5) Intraabdominal hypertension (intraabdominal pressure > 12 mmHg) 6) Pregnant women 7) Transplanted kidney or transplanted liver patients 8) Patients with do-not-resuscitate orders or decisions to withhold life-sustaining treatments 9) Patients or their legally authorized representatives decline to participate 10) Inadequate POCUS image quality, such as the inability to assess the Doppler ultrasonography view
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilator-free days 28 days after the enrollment days / days from the end of mechanical ventilation to day 28. If a patient dies within the first 28 days, their VFD count is zero. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality 28 days after the enrollment categorical data,VExUS score 3 days after the enrollment 0-3 / categorical data,LUS score 3 days after the enrollment 0 to 32 / continuous data,Length of ICU stay until discharge from ICU days / continuous data,Cumulative fluid balance 3 days after the enrollment liters / continuous data | — |
Countries
Thailand
Contacts
Public ContactRanistha Ratanarat
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed