Comparison of differences in opioid analgesics use after Anterior cruciate ligament reconstruction between patients who received etoricoxib with and without nefopam before the surgery.

Comparison of differences in opioid analgesics use after Anterior cruciate ligament reconstruction between patients who received etoricoxib with and without nefopam before the surgery:A double-blinded randomized controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250413001

Enrollment

Registered

2025-04-13

Start date

2024-10-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with anterior cruciate ligament injury who require anterior cruciate ligament reconstruction ACLR, Opioid, Etoricoxib, Nefopam, multimodal analgesia

Interventions

Patients will receive nefopam 80 mg diluted in 500 mL of 5% dextrose in water, administered over 24 hours prior to surgery, combined with oral etoricoxib 120 mg, taken 1 hour before the operation.,Pat

Experimental Drug,Active Comparator Drug

Pre operative multimodal analgesia group,standard treatment group

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1.Patients from the Department of Orthopaedic Surgery, King Chulalongkorn Memorial Hospital. 2.Diagnosed with anterior cruciate ligament injury and scheduled to undergo ACL reconstruction surgery. 3.Eligible participants are aged between 18 and 50 years . 4.Anterior cruciate ligament injury within 6 months prior to the surgery.

Exclusion criteria

Exclusion criteria: 1. Patients with chronic kidney disease. 2. Patients with concomitant injuries involving other knee ligaments, such as collateral ligaments or posterior cruciate ligament (PCL). 3. Patients with cardiovascular disease. 4. Patients with a history of cardiac surgery, including coronary artery bypass graft (CABG). 5. Patients with a history of gastrointestinal bleeding, peptic ulcer disease, or gastric ulcer. 6. Patients with epilepsy. 7. Patients with a history of stroke or brain surgery. 8. Patients with glaucoma. 9. Patients with benign prostatic hyperplasia (BPH). 10. Patients with a history of cerebrovascular disease or intracranial surgery. 11. Patients with known allergies to NSAIDs, opioids, sulfonamides, or nefopam. 12. Patients with a history of opioid addiction.

Design outcomes

Primary

Measure	Time frame
Morphine consumption 12,24,36 hour post operative mg	—

Secondary

Measure	Time frame
The Visual Analogue Scale (VAS) 6,12,24,36 hour post operative 10-centimeter (100 mm) horizontal line	—

Countries

Thailand

Contacts

Public ContactChatchai Suebnukarn

Department of Orthopedics, Faculty of Medicine, Chulalongkorn University.

tewchat@hotmail.com02 256 4000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026