the effect of proximal adductor canal block versus two -point injection at proximal and distal adductor block for pain control after total knee arthroplasty: Randomized control trial

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250407001

Enrollment

Registered

2025-04-07

Start date

2024-06-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain after total knee arthroplasty in patients with knee osteoarthritis. This study focuses on managing acute pain occurring in the first 48 hours after surgery, which is commonly severe and affects patient recovery and mobilization. The study evaluates two techniques of adductor canal nerve block single versus dual-point injection to determine the more effective method for pain control. Total Knee Arthroplasty Postoperative Pain Adductor Canal Block Peripheral Nerve Block

Interventions

Participants assigned to this group will receive a single injection of local anesthetic at the proximal adductor canal under real-time ultrasound guidance prior to total knee arthroplasty. The procedu

Experimental Procedure/Surgery,Active Comparator Procedure/Surgery

Proximal Adductor Canal Block,Two-Point Adductor Canal Block

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1 Patients aged 18 years or older 2 Scheduled for elective primary total knee arthroplasty at Sawanpracharak Hospital 3 ASA physical status classification I to III

Exclusion criteria

Exclusion criteria: 1 Revision total knee arthroplasty on the same side 2 Inability to communicate effectively in Thai 3 Known allergy to any study medications including local anesthetics, opioids, sulfonamides, or parecoxib 4 Contraindications to spinal anesthesia such as coagulopathy (INR > 1.5), platelet count < 100,000, or infection at the puncture site 5 Contraindications to study medications such as eGFR < 50, history of stroke, thromboembolic events, or coronary artery disease 6 Pre-existing neuromuscular disorders affecting the lower limbs 7 Severe obesity (BMI > 40)

Design outcomes

Primary

Measure	Time frame
Pain score at rest 6, 12, and 24 hours after surgery Visual Analog Scale (VAS), scored from 0 (no pain) to 10 (worst pain)	—

Secondary

Measure	Time frame
Pain score during movement 6, 12, and 24 hours postoperatively Visual Analog Scale (VAS), scored from 0 to 10,Time to first opioid request Within 24 hours postoperatively Minutes from end of surgery to first opioid administration,Total opioid consumption Cumulative over 24 hours postoperatively Total morphine dose (mg) administered within 24 hours,Quadriceps muscle strength At 6 and 24 hours postoperatively Manual Muscle Testing (MMT) grade	—

Measure

Time frame

Pain score during movement 6, 12, and 24 hours postoperatively Visual Analog Scale (VAS), scored from 0 to 10,Time to first opioid request Within 24 hours postoperatively Minutes from end of surgery to first opioid administration,Total opioid consumption Cumulative over 24 hours postoperatively Total morphine dose (mg) administered within 24 hours,Quadriceps muscle strength At 6 and 24 hours postoperatively Manual Muscle Testing (MMT) grade

—

Countries

Thailand

Contacts

Public ContactTatcha Tratornpisuttikul

Sawanpracharak Hospital

vimtatcha@hotmail.com0858152360

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026