Effect of Probiotics as an Adjunctive Treatment for Laryngopharyngeal Reflux Disease Probiotics , Laryngopharyngeal Reflux Disease , effect
Conditions
Interventions
Probiotics capsule 500 mg oral daily dose for 8 weeks,Placebo capsule 500 mg oral daily dose for 8 weeks
Experimental Dietary Supplement,Placebo Comparator No treatment
Sponsors
HRH Princess Maha Chakri Siridhorn Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-65 years old 2.confirm diagnosis of laryngopharyngeal reflux disease
Exclusion criteria
Exclusion criteria: 1. Peptic/duodenal ulcer,gastrointestinal bleeding , malabsorption , gastrointestinal cancer 2.history of gastrintestinal surgery 3.patient with adverse effect of probiotics 4.pregnancy or lactating woman 4.caution with probiotic e.g.immunocompromise, prosthetic heart valves, impaired intestine function, central venous catheter, jejunostomy, broad-spectrum antimicrobials and poorly control diabetes mellitus 5. Caution to omeprazole , antacid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the efficacy Of probiotics as adjunctive treatment laryngopharyngeal reflux comparison with placebo controlled 8 weeks Using reflux symptom score(RSS) , Reflux sign assessment(RSA) | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison the quality of life and side effect of probiotics in adjunctive treatment laryngopharyngeal reflux disease 8 weeks Using voice handicap index(VHI) , Short form survey(SF-36) | — |
Countries
Thailand
Contacts
Public ContactPanuwat Wongwattana
Srinakharinwirot university
Outcome results
None listed