Effect of Positive-End Expiratory Pressure on Intracranial pressure in post cranial surgery by ultrasonic imaging measurement the optic nerve sheath diameter

Effect of Positive-End Expiratory Pressure on Intracranial pressure(PEEP) in post cranial surgery by ultrasonic imaging measurement the optic nerve sheath diameter(ONSD)

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250404002

Enrollment

Registered

2025-04-04

Start date

2025-02-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post cranial surgical subject need to know the optimal PEEP for treatment respiratory failure. PEEP,ICP,ONSD

Interventions

Positive-End Expiratory Pressure from mechanical ventilator start at 5 cmH2O(baseline).Then increasing the PEEP level to 8,10,13,15,18,20,22 cmH2O.Each PEEP level has to wait for 2 minutes for effect

Experimental Procedure/Surgery

Positive-End Expiratory Pressure

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.older than 18 year old,2.postcranial surgery,3.on mechanical ventilator

Exclusion criteria

Exclusion criteria: 1.ICP>20mmHg,2.previous brain injury,3.previous eye disease,4.unstable cardiopulmonary ,5.pregnant,6.No inform consent

Design outcomes

Primary

Measure	Time frame
optic nerve sheath diameter 2 minutes after each positive end expiratory pressure(PEEP) levels at8,10,13,15,18,20 and 22 cmH2O. ultrasound imaging ,measurement in mm the size on millimeter(mm)	—

Secondary

Measure	Time frame
mean arterial pressure(MAP),end tidal carbon dioxide(EtCO2),oxygen saturation(SpO2),arterial blood gas(ABG),chest X-ray(CXR) 2 minutes after each PEEP levels at8,10,13,15,18,20 and 22 centimeterwater (cmH2O) MAP in millimeter mercury(mmHg),EtCO2 in mmHg,SpO2 in percentage, ABG in numeric number, CXR by Image results	—

Countries

Thailand

Contacts

Public ContactAnan Chueasuwan

Bhumibol Adulyadej hospital

research.Bhumibol@outlook.co.th0836997999

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026