Keratosis pilaris on the outer arms Atopic dermatitis, Erythema, Follicular hyperkeratosis, Hyperpigmentation, Roughness
Conditions
Interventions
Applied combined salicylic acid, licochalcone A, and isobutylamido thiazolyl resorcinol to one arms twice daily for 12 weeks ,Applied 10% urea cream to the contralateral arm twice daily for 12 weeks
Experimental Drug,Active Comparator Drug
Trio agent ,Urea
Sponsors
Division of Dermatology, Department of medicine, Faculty of Medicine, Ramathibodi hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Participants diagnosed with keratosis pilaris (KP) on both arms 2. Participants must voluntarily agree to participate in the study by signing an informed consent form 3. Participants must discontinue the use of any topical or systemic treatments for KP, for example; keratolytics (e.g., urea, lactic acid, salicylic acid, etc.), retinoids and corticosteroids at least 4 weeks
Exclusion criteria
Exclusion criteria: 1. Participants with major underlying conditions 2. Pregnancy or lactation 3. Presence of active skin disorders at the study sites 4. Known hypersensitivity to salicylic acid, urea, or any ingredient in the study agent 5. Participants with a history of laser or intense pulsed light treatments for KP within 6 months prior to enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin roughness Baseline, week 4, week 8, week 12 Antera 3D,Skin hyperpigmentation Baseline, week 4, week 8, week 12 Antera 3D,Skin erythema Baseline, week 4, week 8, week 12 Antera 3D | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement score Week 12 A 10-cm visual analog scale rated by a blinded physician and patients ,Favorable score Week 12 A 10-cm visual analog scale rated by patients | — |
Countries
Thailand
Contacts
Public ContactVasanop Vachiramon
Faculty of Medicine, Ramathibodi hospital
Outcome results
None listed