Post-operative nausea and vomiting in adult patients undergoing abdominopelvic surgeries PONV Dexmedetomidine Epidural
Conditions
Interventions
During peritoneal closure, 1 mg/kg of dexmedetomidine and 2 mg of morphine (total volume 5 ml) were administered epidurally. ,During peritoneal closure, 2 mg of morphine in NSS 5 ml was administered
Active Comparator Drug,Placebo Comparator Drug
Dexmedetomidine ,Control
Sponsors
Srinakharinwirot University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 65 years old, 2. American Society of Anesthesiologists physical status of I - III, 3. Undergoing elective abdominal pelvic surgery
Exclusion criteria
Exclusion criteria: 1. Contraindication to epidural anesthesia, 2. Allergic history to any of the study drugs, 3. Obesity, 4. Uncontrolled hypertension, 5. Child class C cirrhosis, 6. Renal insufficiency requiring renal replacement therapy, 7. Second and third degree atrioventricular block, 8. Comorbidities known to increase the risk of PONV, 9. Chronic pain requiring preoperative opioid use, 10. Use of antiemetics, glucocorticoid or psychotropic drugs within 24 hours preoperatively
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative nausea and vomiting (PONV) at 1 hour At 1 hour after operation Incidence | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative nausea and vomiting (PONV) at 6 hour At 6 hours after operation Incidence ,Nausea At 1 hour after operation Severity score ,Shivering At 1 hour after operation Incidence ,Postoperative opioid consumption Within 24 hours after operation Morphine equivalent ,Bradycardia During operation Incidence ,Hypotension During operation Incidence | — |
Countries
Thailand
Contacts
Public ContactPiyawan Koopredechat
Srinakharinwirot University
Outcome results
None listed