Participant with photo damaged skin non-crosslink hyaluronic acid, facial rejuvenation
Conditions
Interventions
Patient receive 3 treatment session with non crosslinked hyaluronic acid. Patient the follow up at 1-,3-,6- and 9 months after complete treatment
Experimental Device
non cross
linked hyaluronic acid injection
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age from 20-60 years, both male and female. 2. Individuals with early-stage sun-damaged skin, assessed by any of the following criteria: 2.1. Uneven skin tone 2.2. Fine lines 2.3. Dry skin 2.4. Sagging skin 3. Thai of Asian descent. 4. Participants who consent to join the project voluntarily and agree to receive injections of fillers with the quantity and at the positions specified in the research protocol.
Exclusion criteria
Exclusion criteria: 1. Pregnant women or those breastfeeding. 2. Participants with a history of abnormal platelet disorders or abnormal blood clotting, anemia, liver disease, cancer, autoimmune deficiency. 3. Participants who smoke and have a history of heavy alcohol consumption. 4. Participants with inflammatory skin rashes (dermatitis), wounds, or infected skin on the face. 5. Participants with a history of local anesthetic allergy. 6. Participants with a history of taking hormones or contraceptives, including injectable forms or regular NSAIDs. 7. Participants with a history of taking medications that affect blood clotting, such as aspirin and anticoagulants. 8. Participants with a history of facial lifting procedures, including lifting devices or thread lifting, within 6 months prior to joining the research project. 9. Participants who have had facial fillers injected within 6 months before joining the research project. 10. Participants who have had injections of concentrated platelet-rich plasma in the face within 6 months before joining the research project. 11. Participants who have had botulinum toxin injections in the face within 6 months before joining the research project. 12. Participants who have undergone facial collagen-stimulating laser treatments, such as Picosecond laser, Erbium: YAG laser, Fractora, or Laser E matrix within 6 months before joining the research project. 13. Participants with hypertrophic scars. 14. Participants with a diagnosed mental disorder by a psychiatrist. 15. Participants who do not consent to having photographs taken for treatment assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin wrinkle Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment Antera 3D,skin texture Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment Antera 3D | — |
Secondary
| Measure | Time frame |
|---|---|
| skin hydration Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment corneometer,volume change Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment vectra,skin melanin Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment mexameter,skin erythema Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment mexameter,skin individual topology angle Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment colorimeter,skin sebum Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment sebumeter,physician assessment Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment photo,adverse event Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment note,patient improvement score Baseline, 1 month after 1st treatment, 1 month after 2nd treatment, 1-,3- and 6 months after complete treatment GAIS,Pain score Baseline, 1 month after 1st treatment, 1 month after 2nd treatment visual analog score | — |
Countries
Thailand
Contacts
Public ContactRungsima Wanitphakdeedecha
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed