ASSOCIATIONS OF VITAMIN D RECEPTOR GENE POLYMORPHISMS AND SERUM VITAMIN D WITH TREATMENT RESPONSES IN METASTATIC COLORECTAL CANCER PATIENTS ON CHEMOTHERAPY

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20250320001

Enrollment

135

Registered

2025-03-20

Start date

2025-03-04

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metastatic colorectal cancer Colorectal cancer, genetic polymorphism, treatment outcome, vitamin D, vitamin D receptor

Interventions

Metastatic colorectal cancer patients

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Histologically and cytologically proven mCRC patients 2. Aged > 18 years receiving first cycle of chemotherapy with ECOG performance status 0-1 3. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Patients with cognitive impairment 2. Illiterate participants 3. Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
Treatment response After third cycle of chemotherapy Response Evaluation Criteria in Solid Tumors (RECIST)	—

Secondary

Measure	Time frame
Serum vitamin D At baseline LIAISON 25 OH Vitamin D TOTAL Assay	—

Countries

Thailand

Contacts

Public ContactTippawan Siritientong

Faculty of Pharmaceutical Sciences, Chulalongkorn University

tippawan.s@pharm.chula.ac.th66619562898

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026