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Comparison of intrathecal morphine 0.1 mg plus intravenous acetaminophen with intrathecal morphine 0.2 mg on efficacy and side effects in cesarean section : A randomized non-inferiority trial

Comparison of intrathecal morphine 0.1 mg plus intravenous acetaminophen with intrathecal morphine 0.2 mg on efficacy and side effects in cesarean section : A randomized non-inferiority trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250319004
Enrollment
100
Registered
2025-03-19
Start date
2024-01-08
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female patient whom was scheduled for elective cesarean section with spinal anaesthesia at Ramathibodi Hospital Intrathecal morphine, intravenous acetaminophen, analgesic efficacy

Interventions

Intrathecal morphine 0.1 mg plus intravenous acetaminophen measured on efficacy and side effects in cesarean section. Patients were assessed for pain using the verbal pain score (VPS) on a scale of 0-
Active Comparator Drug,Active Comparator Drug
intrathecal morphine 0.1 mg plus intravenous acetaminophen,intrathecal morphine 0.2 mg

Sponsors

Faculty of Medicine Ramathibodi Hospital, Mahidol University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to No maximum

Inclusion criteria

Inclusion criteria: 1 female patient whom was scheduled for elective cesarean section with spinal anesthesia 2 gestational age of greater than or equal to 34 weeks 3 ASA status 2 4 consent provide

Exclusion criteria

Exclusion criteria: 1 pregnancies with complications; PIH, twin pregnancy, fetal distress, multiple gestations 2 patients with contraindications of spinal anesthesia 3 patients with pregestational BMI greater than 25 kg/m2 4 patients with allergy to study medications 5 consent withdrawn

Design outcomes

Primary

MeasureTime frame
analgesic efficacy 48 hours verbal pain scales (VPS)

Secondary

MeasureTime frame
side effects 48 hours time to first analgesic requirement, side effects, antiemetic drug use, antipruritic drug use and satisfaction score

Countries

Thailand

Contacts

Public ContactSaranporn Charoensawat

Faculty of Medicine Ramathibodi Hospital, Mahidol University

ononsrp5@gmail.com66910791181

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026