healthy volunteer triamcinolone acetonide, microneedling radio-frequency, percutaneous drug absorbtion
Conditions
Interventions
Triamcinolone acetonide was drop to patient forearm. It was then leave for 6 hours. Clear tape was striped to patient forearm. the level of triamcinolone acetonide was measured.,Microneedle Depth 0.5m
Experimental Device,Experimental Device,Experimental Device,Experimental Device,Experimental Device,Experimental Device,Experimental Device,Experimental Device
TA only,Microneedle Depth 0.5mm RF level 2 (420mJ) with TA,Microneedle Depth 0.5mm RF level 5 (1300mJ) with TA,Microneedle Depth 2.5mm RF level 2 (420mJ) with TA,Microneedle Depth 2.5mm RF level 5 (13
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. age 18 to 60 years old 2. healthy volunteer with no skin lesion at forearm 3. consent to receive treatment
Exclusion criteria
Exclusion criteria: 1. pregnancy or breastfeeding 3 months prior to study 2. dermatitis or active skin lesion at forearm 3. have prior treatment including laser, skin toning at forearm 4 weeks prior to study 4. steroid hypersensitivity 5. have photohypersitivity rash 6. chronic use of steroid, heavy smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the level of triamcinolone acetonide solution after study Ultra high-performance liquid chromatography | — |
Secondary
| Measure | Time frame |
|---|---|
| transepidermal water loss after study transepidermal water loss (TEWL)meter | — |
Countries
Thailand
Contacts
Public ContactRungsima Wanitphakdeedecha
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed