Pre-frail elderly participants who do not supplement with vitamins B and D. Aging-related diseases Elderly population Frailty syndrome Nutrition Epigenetics Epigenetic biomarkers DNA methylation Vitamin B9 Vitamin B12 Vitamin D Depression Dementia Immunosenescence
Conditions
Interventions
Participants in the control group were administered a placebo designed to mimic the appearance and characteristics of the active vitamin supplements.,Participants in Group B were administered vitamin
Placebo Comparator No treatment,Active Comparator Dietary Supplement,Active Comparator Dietary Supplement,Active Comparator Dietary Supplement
Sponsors
National Research Council of Thailand (NRCT)
Eligibility
Sex/Gender
All
Age
60 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Thai elderly participances age 60 years or older, 2. Participances must meet the pre-frail criteria as assessed by the Fried frailty phenotypes.
Exclusion criteria
Exclusion criteria: 1. Individuals with communication difficulties, 2. Persons who score below 18 on the Thai Mental State Examination, 3. Persons in the terminal stage of life with a life expectancy of less than 6 months, 4. Elderly individuals with uncontrolled chronic diseases, such as those with respiratory or circulatory failure, 5. Individuals with chronic kidney disease, 6. Persons with physical impairments, such as amputations or deformities of the legs and feet, including paralysis and weakness, 7. Persons who have received blood transfusions, had acute infections, or vaccinations within the last month, 8. Persons with chronic infections and those on immunosuppressive or immunostimulatory drugs, 9. Persons who have taken or are currently taking any of the following: B complex, B9, B12, or D vitamins within the 4 months prior to study enrollment, 10. Persons with vitamin D levels less than 30 nmol/L.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physical characteristics at 6 and 12 months after the intervention chair stand, functional reach, gait speed in 4 meters, hand grip strength, and sit and reach,Blood parameters at 6 and 12 months after the intervention chemiluminescence, electrical resistance, hydrodynamic focusing, SLS-haemoglobin, and high-performance liquid chromatography methods and Chronic Kidney Disease Epidemiology Collaboration equation,Neurodegenerative disease at 6 and 12 months after the intervention Thai Mental State Examination (TMSE), Montreal Cognitive Assessment-Thai version (MOCA-Thai),Genetics and epigenetics at 6 and 12 months after the intervention sanger sequencing, Infinium MethylationEPIC array, bioinformatic analysis,Depressive disorder at 6 and 12 months after the intervention Thai Geriatric Depression Scale (TGDS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Vitamins knowledge and understanding Cross-sectional at the recruiment questionnaire,Food screener for DNA methylation level at 6 and 12 moths after the intervention diet quality questionnaire, food record | — |
Countries
Thailand
Contacts
Public ContactChanachai Sae Lee
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed