Patient with Photodamage skin facial rejuvenation, VYC-12L Injection
Conditions
Interventions
Participants were injected with VYC-12L Hyaluronic acid at both side of face. Participants were then follow up at 1-,2-,3-.6- and 9 months after treatment
Experimental Drug
VYC-12L Hyaluronic acid
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age from 20-60 years, both male and female. 2. Individuals with early-stage sun-damaged skin, assessed by any of the following criteria: 2.1. Uneven skin tone 2.2. Fine lines 2.3. Dry skin 2.4. Sagging skin 3. Thai of Asian descent. 4. Participants who consent to join the project voluntarily and agree to receive injections of fillers with the quantity and at the positions specified in the research protocol.
Exclusion criteria
Exclusion criteria: 1. Participants who are pregnant or breastfeeding. 2. Participants with a history of abnormal platelet disorders or abnormal blood clotting, anemia, liver disease, cancer, autoimmune deficiency. 3. Participants who smoke and have a history of heavy alcohol consumption. 4. Participants with inflammatory skin rashes (dermatitis), wounds, or infected skin on the face. 5. Participants with a history of local anesthetic allergy. 6. Participants with a history of taking hormones or contraceptives, including injectable forms or regular NSAIDs. 7. Participants with a history of taking medications that affect blood clotting, such as aspirin and anticoagulants. 8. Participants with a history of facial lifting procedures, including lifting devices or thread lifting, within 6 months prior to joining the research project. 9. Participants who have had facial fillers injected within 6 months before joining the research project. 10. Participants who have had injections of concentrated platelet-rich plasma in the face within 6 months before joining the research project. 11. Participants who have had botulinum toxin injections in the face within 6 months before joining the research project. 12. Participants who have undergone facial collagen-stimulating laser treatments, such as Picosecond laser, Erbium: YAG laser, Fractora, or Laser E matrix within 6 months before joining the research project. 13. Participants with hypertrophic scars. 14. Participants with a diagnosed mental disorder by a psychiatrist. 15. Participants who do not consent to having photographs taken for treatment assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average Wrinkle Baseline,1-,2-,3-.6- and 9 months after treatment antera,Average texture Baseline,1-,2-,3-.6- and 9 months after treatment antera | — |
Secondary
| Measure | Time frame |
|---|---|
| volume change Baseline,1-,2-,3-.6- and 9 months after treatment Vectra H2,skin elasticity Baseline,1-,2-,3-.6- and 9 months after treatment cutometer,melanin Baseline,1-,2-,3-.6- and 9 months after treatment mexameter,erythema Baseline,1-,2-,3-.6- and 9 months after treatment mexameter,Individual topography angle Baseline,1-,2-,3-.6- and 9 months after treatment colorimeter,Sebum level Baseline,1-,2-,3-.6- and 9 months after treatment Sebumeter,physician assessment Baseline,1-,2-,3-.6- and 9 months after treatment photo,patient assessment Baseline,1-,2-,3-.6- and 9 months after treatment global aesthetic improvement score,pain score treatment visual analog score | — |
Countries
Thailand
Contacts
Public ContactRungsima Wanitphakdeedecha
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed