Cumulative opioid consumption during the first 24 hours postoperative period after lateral QLB in adult patients undergoing deceased donor kidney transplantation (CDKT) Quadratus lumborum block Kidney transplant Pain management
Conditions
Interventions
Lateral quadratus lumborum block (QLB) using 0.3% bupivacaine with adrenaline (1:200,000) and dexmedetomidine (1 mcg/kg), total volume 30 mL,The control group will receive standard pain management wit
Lateral quadratus lumborum block,Control
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Undergoing deceased donor kidney transplantation 2. American Society of Anesthesia (ASA) physical status III 3. Have ability to communicate and understand the study and accept to participate in the study 4. Body weight > 45 kg.
Exclusion criteria
Exclusion criteria: 1. Patients who have following underlying disease: hepatic impairment (diagnosed of cirrhosis or evidence of abnormal liver function test which are increased liver enzymes or bilirubin level), coagulopathy (diagnosed of disease associated with abnormal coagulation, currently use any anticoagulants or evidence of prolong prothrombin time (PT) or partial thromboplastin time (PTT)), morbid obesity (BMI >35 kg/m2), pre-existing neurological deficits, chronic pain (diagnosed of chronic pain disease or current use regular analgesic drugs), or any drug addiction. 2. Known allergy to local anesthetics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative opioid consumption 24 hours postoperatively Total fentanyl consumption (measured in micrograms) over the first 24 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Early recovery QoR-15 assessed at 24 and 48 hours postoperatively; length of hospital stay recorded at discharge Quality of Recovery-15 (QoR-15) questionnaire score and length of hospital stay (in days),Graft outcome CCR2 at day 2; urine output monitored postoperatively; delayed graft function rate assessed up to 1 month post-surgery. Creatinine reduction ratio (CCR2) at day 2, urine output, and rate of delayed graft function (DGF),Opioid consumption Intraoperative and at 48 hours postoperatively Intraoperative fentanyl consumption and total opioid consumption at 48 hours postoperatively,Pain intensity At 0, 4, 8, 12, 16, 20, and 24 hours postoperatively Postoperative pain intensity assessed using the Numerical Rating Scale (NRS 0-10),5. Complication associated block Assessed after block Incidence of hematoma, vascular injection, and local anesthetic systemic toxicity (LAST) | — |
Countries
Thailand
Contacts
Public ContactArtid Samerchua
Chiang Mai University
Outcome results
None listed