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The efficacy of combined subcision and microfocused ultrasound with visualization for improving atrophic acne scars: A split-face randomized comparative study

The efficacy of combined subcision and microfocused ultrasound with visualization for improving atrophic acne scars: A split-face randomized comparative study

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250310003
Enrollment
40
Registered
2025-03-10
Start date
2024-01-03
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne scars Atrophic scars Acne scars Atrophic scars Subcision Microfocused ultrasound

Interventions

The involved area with acne scars was cleaned using 2% chlorhexidine in 70% alcohol solution and locally anesthesized using 2% lidocaine with adrenaline. Subcision was performed using a blunt cannula
Combined subcision and MFU-V,Subcision monotherapy

Sponsors

Dermatology Division, Internal Medicine Department, Ramathibodi Hospital, Mahidol University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (i) 18 to 60 years old (ii) Atrophic acne scars (mild to severe)

Exclusion criteria

Exclusion criteria: (i) History of laser/energy-based/injectable/topical therapy on the cheeks area within the past 12 months (ii) Severe medical condition (iii) Other active dermatological diseases (iv) Immunocompromised status (v) Pregnancy or lactation (vi) Currently taking antiplatelets or anticoagulants (vi) History of keloids formation (vii) Metal implant in the facial region.

Design outcomes

Primary

MeasureTime frame
Depression volume Baseline, 1, 3, 6 and 9 months post treatment Antera 3D camera (mm3),Modified ECCA Grading Scale Baseline, 1, 3, 6 and 9 months post treatment Subjective evaluation by a blinded physician,Modified Qualitative Global Scarring Grading System Baseline, 1, 3, 6 and 9 months post treatment Subjective evaluation by a blinded physician,Patient satisfaction Baseline, 1, 3, 6 and 9 months post treatment Visual analogue scale,Pain score Immediately after procedure Visual analogue scale

Secondary

MeasureTime frame
Adverse events and theirs durations Through out study Subjective evaluation by patient

Countries

Thailand

Contacts

Public ContactNatthachat Jurairattanaporn

Faculty of Medicine Ramathibodi Hospital, Mahidol University

natthachat.j.md@gmail.com022004287

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026