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The efficacy of delayed trans-intraarticular catheter Methylprednisolone and Bupivacaine injection as an adjunct to multimodal analgesia to decrease pain after discharge in Total Knee Arthroplasty: An ambi-directional cohort study

The efficacy of delayed trans-intraarticular catheter Methylprednisolone and Bupivacaine injection as an adjunct to multimodal analgesia to decrease pain after discharge in Total Knee Arthroplasty: An ambi-directional cohort study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250309004
Enrollment
130
Registered
2025-03-09
Start date
2025-07-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post operative pain management in total knee arthroplasty after the patient was discharged from hospital. Post operative pain management in total knee arthroplasty Pain after discharge Post operative pain management

Interventions

Patients undergoing MIS-TKA performed by one of four experienced orthopedic surgeons specializing in hip and knee arthroplasty and receiving multimodal analgesia as pain management protocol. - Spinal
Experimental Drug,No Intervention No treatment
Intervention group,Control group

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
50 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with primary osteoarthritis undergoing primary unilateral total knee arthroplasty (TKA). 2. Age more than 50 years old 3. The patient receive multimodal analgesia as pain management protocol.

Exclusion criteria

Exclusion criteria: 1. History of steroid allergy. 2. Impaired gait or balance. 3. Coexisting conditions involving the spine, hip, ankle, or other conditions affecting TKA outcomes. 4. Communication impairment preventing questionnaire responses.

Design outcomes

Primary

MeasureTime frame
The incidence of pain with a severity greater than 3 on the Numerical Rating Scale (NRS) at POD 5 Post operative day 5 Pain score using Numerical Rating Scale (NRS)

Secondary

MeasureTime frame
Pain levels at rest and during activity in both patient groups preoperative and POD 1 day to 2 weeks (daily), and 3 weeks to 8 weeks (weekly), using the Numerical Rating Scale (NRS). Pre operative until 8 weeks post operative Pain score using Numerical Rating Scale (NRS),Range of motion Pre operative, 1 day, 2 days , 2 weeks, 6 weeks post operative Direct measurement by goniometer,WOMAC score Pre operative, 1 day, 2 days , 2 weeks, 6 weeks post operative Patient reported outcome using a questionnaire interview,KOOS-12 score Pre operative, 1 day, 2 days , 2 weeks, 6 weeks post operative Patient reported outcome using a questionnaire interview,5 time sit-to-stand test Pre operative, 1 day, 2 days , 2 weeks, 6 weeks post operative Functional test performed by patient,Time up-and-go test Pre operative, 1 day, 2 days , 2 weeks, 6 weeks post operative Functional test performed by patient,Complication Pre operative until 8 weeks post operative Observed by research team,Opioid consumption Post operative day 0,1, and 2 Recorded by staff

Countries

Thailand

Contacts

Public ContactKanitsorn Pakdeethitipaibul

King Chulalongkorn Memorial Hospital

sornmdcu@gmail.com0816147773

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026