High-Dose Nebulized Corticosteroids as Adjunctive Therapy for wheezing child: A Multicenter Randomized, Double-Blind Controlled Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250306004

Enrollment

160

Registered

2025-03-06

Start date

2025-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Child with first episode wheezing First episode wheezing

Interventions

Add on High dose budesonide nebulization to the standard treatment Budesonide 1000 mcg plus Adrenaline(1:1000) 1 ml plus 3%NaCl 2 ml nebulization every 12 hours,Standard treatment with Adrenaline(1:1

Experimental Drug,Experimental Drug

Add on High dose budesonide Group,Standard group

Eligibility

Sex/Gender

All

Age

1 Months to 5 Years

Inclusion criteria

Inclusion criteria: 1. Patient, age less than 5 years old 2. presented with first episode of wheezing 3. admitted in the pediatric ward of Ramathibodi Hospital 4. Receive parental consent

Exclusion criteria

Exclusion criteria: 1. Known diagnosis of asthma, recurrent wheezing, chronic lung disease 2. Allergic to epinephrine, budesonide 3.Deny consent from parent

Design outcomes

Primary

Measure	Time frame
Length of stay 6 month Days/ Mean and Median length of stay	—

Secondary

Measure	Time frame
Clinical Severity score 24, 48, 72, 96 and 120 hours after intervention Numberical score/ Repeated measuremens Over Time,Nurse satification score 72 hours after intervention points	—

Countries

Thailand

Contacts

Public ContactThitichaya Leesurapong

Faculty of Medicine Ramathibodi Hospital, Department of Pediatrics

thitiform@gmail.com0873874095

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026