Onset time of ultrasound-guided infraclavicular blocks using Bupivacaine with Dexmedetomidine in patients undergoing upper extremity surgery (distal to the elbow) Brachial plexus block Dexmedetomidine Bupivacaine
Conditions
Interventions
Bupivacaine 0.5% ,Bupivacaine 0.5% with dexmedetomidine 0.67 mcg/kg ,Bupivacaine 0.5% with dexmedetomidine 1.33 mcg/kg
D0,D1,D2
Sponsors
Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) risk classification 1, 2 or 3. 2. Body mass index between 20 and 35. 3. Patients undergoing upper extremity surgery at or distal to the elbow.
Exclusion criteria
Exclusion criteria: 1. Adults who cannot give their own consent 2. Adults who do not understand or speak Thai or Spanish 3. Pre-existing clinical neuropathy (determined by history and physical examination. 4. Coagulopathy (determined by history and physical examination, and if deemed necessary by coagulation test: platelet count less than 100,000, international normalized ratio INR more than 1.4) 5. Renal failure (determined by history and physical examination, and if deemed necessary by plasma creatinine test more than 1.2) 6. Liver failure (determined by history and physical examination, and if deemed necessary by transaminase test more than 100) 7. Allergy to local anesthetics (LAs) 8. Pregnancy or breastfeeding 9. Previous surgery in the ipsilateral infraclavicular fossa 10. Chronic pain syndromes requiring chronic opioid consumption at home
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset Time (the time required to reach a minimum of 14 points) Every 5 minutes for 60 minutes Assessment of sensory and motor blockade (a maximum of 16 points) | — |
Secondary
| Measure | Time frame |
|---|---|
| Imaging Time During the performance of the infraclavicular brachial plexus block The time interval between the contact of the US transducer with the patient and the acquisition of a satisfactory picture,Needling time During the performance of the infraclavicular brachial plexus block The temporal interval between the skin infiltration and the end of LA injection through the block needle,Performance Time During the performance of the infraclavicular brachial plexus blockDuring the performance of the infraclavicular brachial plexus block The sum of imaging and needling times ,Number of needle passes During the performance of the infraclavicular brachial plexus block The initial needle insertion will count as the first pass. Any subsequent needle advancement that is preceded by a retraction of at least 10 mm will count as an additional pass.,Procedural Pain Within 15 minutes after the infraclavicular brachial plexus block Numeric rating scale (0-10),Success Rate (surgical anesthesia) During the operation The ability to proceed with surgery without the need for intravenous narcotics, general anesthesia, rescue blocks or LA infiltration by the surgeon,Duration of the Sensory Block Within 48 hours after surgery The temporal interval between the end of LA injection through the block needle and the return of sensation to the hand and fingers,Duration of the Motor Block Within 48 hours after surgery The temporal interval between the end of LA injection through the block needle and the return of movement to the hand and fingers,Duration of Analgesia Within 48 hours after surgery The temporal interval between the end of LA injection through the block needle and the appearance of pain at the surgical site,Complications Within 48 hours after surgery Occurrence of vascular puncture, paresthesia, pneumothorax, LA toxicity, bradycardia, hypotension, sedation/ oxygen desaturation | — |
Countries
Thailand
Contacts
Public ContactPrangmalee Leurcharusmee
Chiang Mai University
Outcome results
None listed