Chronic Obstructive Pulmonary Disease Exacerbation Chronic Obstructive Pulmonary Disease, Emergency Department, Diaphragmatic Dysfunction, Point-of-Care Ultrasound
Conditions
Interventions
Budesonide 2000 mcg (1000 mcg/2 ml, 2 respules) and 1.25 mg fenoterol and 0.5 mg ipratropium bromide q 20 minutes x 3 doses,Normal saline 4 ml and 1.25 mg fenoterol and 0.5 mg ipratropium bromide q 20
Experimental Drug,Placebo Comparator Drug
Sponsors
Thai College of Emergency Physicians (TCEP)
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Volunteers aged 40 years or older, 2.Diagnosed as COPD, 3.Having symptoms and signs of exacerbation of COPD
Exclusion criteria
Exclusion criteria: 1.Presence of respiratory failure with indications for endotracheal intubation, 2.Indications for the use of non-invasive ventilation (NIV), 3.Indications for the use of high-flow nasal cannula (HFNC), 4.History of allergic to corticosteroids, 5.COVID-19 infection, 6.Suspected or diagnosed as disseminated pulmonary tuberculosis infection, 7.Inability to cooperate in pulmonary function testing, 8.Presence of other emergency conditions, 9.Use of systemic steroids or an increase in the dosage of inhaled corticosteroids within the past 7 days, 10. Diagnosed with asthma-COPD overlap syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragmatic Thickening Fraction 1, 2, 3, 4 hours after intervention Percentage | — |
Secondary
| Measure | Time frame |
|---|---|
| NA NA NA | — |
Countries
Thailand
Contacts
Public ContactNipon Diskumpon
Department of Emergency Medicine, Faculty of Medicine, Thammasat University
Outcome results
None listed