COPD patients with acute exacerbation Aerosol therapy Chronic obstructive pulmonary disease Impulse oscillometry High-flow nasal cannula Vibrating mesh nebulizer
Conditions
Interventions
- Step 1: Patients will receive low-flow O2 therapy for 15 min then Step 2: patients will be switched to high-flow nasal cannula for 15 min and then Step 3: patient will receive salbutamol 2.5 mg via
Experimental Device
High-flow nasal cannula with vibrating mesh nebulizer
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 40-85 years 2. Diagnosed COPD according to GOLD guideline 3. Spirometry showed no reversibility within 12months 4. Acute exacerbation of COPD requiring hospital admission
Exclusion criteria
Exclusion criteria: 1. pH < 7.25 2. Respiratory rate > 30 breaths/min 3. SpO2 < 92% while receiving simple nasal cannula </= 3 L/min 4. Impaired level of consciousness or uncooperate 5. Active cardiovascular problem such as hypotension, acute coronary syndrome, or malignant arrhythmia 6. Receiving noninvasive ventilation 7. Contraindication for performing impulse oscillometry 8. Allergy to salbutamol 9. Deny to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference of respiratory resistance at 5 Hz and 20 Hz (R5-R20) 15 minutes Impulse oscillometry | — |
Secondary
| Measure | Time frame |
|---|---|
| Dyspnea 15 minutes Borg Dyspnea scale,Transcutaneous CO2 pressure 15 minutes Sentec monitor,SpO2 15 minutes Pulse oximetry,Respiratory rate 15 minutes Respiratory rate | — |
Countries
Thailand
Contacts
Public ContactDr. Nuttapol Rittayamai
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed