Aloe vera mouthwash in patients with dental caries: a clinical trial

The effect of aloe vera mouthwash on oral microbes in saliva

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250301001

Enrollment

Registered

2025-03-01

Start date

2023-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Participants will rinse their oral cavity with 15 mL of aloe vera mouthwash for 30 seconds, twice a day after toothbrushing for 7 days. Unstimulated whole saliva samples were collected at baseline an

Experimental Drug,Experimental Drug

aloe vera mouthwash,chlorhexidine mouthwash

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. 18 years old or older 2. Having at least 10 teeth in the oral cavity 3.Having at least 2 active caries exhibiting dentin decay lesions classified as International Caries Detection and Assessment System (ICDAS) level 4 or higher, 4. DMFT index of 3 or higher. 5. Not having braces or removable dentures

Exclusion criteria

Exclusion criteria: 1. Having underlying systemic diseases such as diabetes mellitus or significant systemic conditions 2. Having a history of allergy to chlorhexidine, aloe vera, garlic, onions, or tulips. 3. Having treatment with antibiotics within the past 3 months. 4. Pregnancy or lactation 5. Alcoholism

Design outcomes

Primary

Measure	Time frame
Levels of salivary mutans streptococci, lactobacilli, and Candida 7 days Modified dip -slide test	—

Secondary

Measure	Time frame
salivary flow rate, baseline and day 7 after intervention unstimulated salivary flow rate	—

Countries

Thailand

Contacts

Public ContactSuteera Techatanawat

Faculty of Dentistry, Srinakharinwirot University, Thailand

suteerate@m.swu.ac.th0819459520

Outcome results