Popliteal plexus block vs iPACK block: An additional analgesia to distal femoral triangle block in total knee arthroplasty. A randomized clinical trial.

Analgesic efficacy and functional outcome between distal femoral triangle block combined popliteal plexus block and distal femoral triangle block combined infiltration between popliteal artery and posterior knee capsule (iPACK) after total knee arthroplasty: RCT

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250225002

Enrollment

Registered

2025-02-25

Start date

2025-03-04

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee (OA of knee) Total knee arthroplasty Popliteal plexus block Distal femoral triangle block Distal adductor canal infiltration between the popliteal artery and the posterior knee capsule ( iPACK block ) TUG 5STST 2MWT ROM

Interventions

After spinal anesthesia, the patient receives both the distal femoral triangle block and popliteal plexus block via the distal adductor canal in the supine position. The distal femoral triangle block

clock position at the distal adductor canal, just before it transitions into the popliteal artery.,Following spinal anesthesia, the patient is placed in the lateral decubitus position with the operati

Experimental Procedure/Surgery,Experimental Procedure/Surgery

distal femoral triangle block combined popliteal plexus block

(dFTB+PPBgroup) ,distal femoral triangle block combined infiltration between the popliteal artery and the posterior knee capsule ( iPACK)

(dFTB+iPACK group)

Eligibility

Sex/Gender

All

Age

25 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patient who has osteoarthritis of the knee and undergo tatal knee arthroplasty

Exclusion criteria

Exclusion criteria: 1. secondary osteoarthritis, prior knee infections, a history of knee surgery 2. severe hepatic or renal dysfunction 3. opioid tolerance 4. a history of drug allergies used in this study

Design outcomes

Primary

Measure	Time frame
Pain score at PACU,6,12,18 hr post TKA Numeric rating sore ;NRS ,24 hr total morphine consumption 24 hr. post TKA Patient control analgesia device (PCA)	—

Secondary

Measure	Time frame
Functional outcome post op 24 hr Time up and go test (TUG),Functional outcome post op 24 hr Two minute walk test (2MWT),Functional outcome post op 24 hr Five times sit to stand test (5STST),Functional outcome; active knee flexion (AKF) post op 24 hr range of motion (ROM),Post operative nausea and vomitting post op 24 hr 4-point categorical scale ,Patient satisfaction Post op 24 hr 10-point categorical scale ,Length of hospital stay The number of days from surgery to discharge The number of days from surgery to discharge in electronic medical record	—

Measure

Time frame

Functional outcome post op 24 hr Time up and go test (TUG),Functional outcome post op 24 hr Two minute walk test (2MWT),Functional outcome post op 24 hr Five times sit to stand test (5STST),Functional outcome; active knee flexion (AKF) post op 24 hr range of motion (ROM),Post operative nausea and vomitting post op 24 hr 4-point categorical scale ,Patient satisfaction Post op 24 hr 10-point categorical scale ,Length of hospital stay The number of days from surgery to discharge The number of days from surgery to discharge in electronic medical record

—

Countries

Thailand

Contacts

Public ContactDr. Prapairat Hemmaraj

Sukhothai hospital

maple_anes@hotmail.com0882826965

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026