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Comparison between efficacy of Clotrimazole cream and combined antifungal, antibiotic and corticosteroid cream in otomycosis treatment: A randomized controlled trial

Comparison between efficacy of Clotrimazole cream and combined antifungal, antibiotic and corticosteroid cream in otomycosis treatment: A randomized controlled trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250225001
Enrollment
52
Registered
2025-02-25
Start date
2023-10-27
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

otomycosis otomycosis treatment

Interventions

the control group, which received clotrimazole cream 0.5 mL in the ear canal.,the treatment group, which received combined nystatin, neomycin, gramicidin, and triamcinolone acetonide cream 0.5 mL in t
Active Comparator Drug,Experimental Drug
Clotrimazole cream,combined nystatin, neomycin, gramicidin, and triamcinolone acetonide cream

Sponsors

Faculty of Medicine Chiang Mai University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Male and female patients aged 20 to 70 years who were recently diagnosed with otomycosis with no history of otomycosis within the previous 3 months. 2. Immunocompetent patient 3. Participants had provided written informed consent to study participation.

Exclusion criteria

Exclusion criteria: 1. Patient with a history of middle ear surgery such as mastoidectomy. 2. Patient with abnormal anatomy of EAC. 3. Patient with concomitant chronic otitis media or tympanic membrane perforation. 4. Patient with bilateral otomycosis

Design outcomes

Primary

MeasureTime frame
The complete endoscopic response rate 10-14days otoendoscopic examination

Secondary

MeasureTime frame
symptoms score 10-14days Likert score

Countries

Thailand

Contacts

Public ContactTaksinawadee Ratanayon

Faculty of Medicine, Chiang Mai University

taksinawadee.rat@cmu.ac.th896674433

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026