mannitol is the treatment of choice for reducing intracranial pressure. the most commonly used concentration of mannitol is 20% at a dose of 1.0 g/kg, as it effectively reduces brain tension with minimal side effects. However, there are no definitive guidelines on the optimal timing for mannitol administration. mannitol,craniotomy,brain relaxation score
Conditions
Interventions
received 20% mannitol dose 1.0 g/kg immediately after anesthesia induction
,patient received 20% mannitol dose 1.0 g/kg at the time of skin incision
Received immediately after anesthesia induction,Received at the time of skin incision
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients with brain tumors size less than 5 cm. undergoing elective craniotomy 2.Receive mannitol during surgery 3.Aged between 18 and 65 years 4.ASA physical status classification 1-3 5.Glasgow Coma Scale (GCS) score of 13-15
Exclusion criteria
Exclusion criteria: 1. Refuse to participate 2.Preoperative hyponatremia or hypernatremia (serum sodium < 120 or > 150 mmol/L) 3.Preoperative congestive heart failure or respiratory distress 4.Chronic kidney disease stage 3-5 (GFR < 60 mL/min/1.73 m2) 5.Treatment with mannitol, hypertonic saline or diuretics in the previous 24 hours 6.Patients who had undergone external ventricular drainage (EVD) or VP shunt
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| brain relaxation when dura opening brain relaxation score | — |
Secondary
| Measure | Time frame |
|---|---|
| Bispectral index T0: time at mannitol infusion T60: 60 minutes after mannitol infusion T120: 120 minutes after mannitol infusion monitor,Partial pressure carbon dioxide T0: time at mannitol infusion T60: 60 minutes after mannitol infusion T120: 120 minutes after mannitol infusion Showing 1 to 1 of 1 entries arterial blood gas,Intraoperative hemodynamic change: Heart rate, Mean arterial blood pressure, serum lactate, pulse pressure variation, urine output T0: time at mannitol infusion T60: 60 minutes after mannitol infusion T120: 120 minutes after mannitol infusion monitor, arterial blood gas,Incidence of severe electrolyte imbalance: serum sodium,resum potasssium, serum bicabonate T0: time at mannitol infusion T60: 60 minutes after mannitol infusion T120: 120 minutes after mannitol infusion Showing 1 to 1 of 1 entries arterial blood gas,Incidence of significant hemodynamic change T0: time at mannitol infusion T60: 60 minutes after mannitol infusion T120: 120 minutes after mannitol infusion monitor | — |
Countries
Thailand
Contacts
Public ContactNapat Jaitham
Khon Kaen University
Outcome results
None listed