antituberculosis drugs induced liver injury Tuberculosis, Antituberculosis drug, Drug-induced liver injury, Risk factors
Conditions
Interventions
Patients who experienced ATDILI after receiving standard antituberculosis regimen.,Tuberculosis patients who did not experience ATDILI.
Prevention,Prevention
ATDILI,Control
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Tuberculosis patients who have received standard antituberculosis treatment, including Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol. 2. Patients who have undergone liver function tests before and after receiving standard antituberculosis treatment or before and after experiencing Antituberculosis drugs-induced liver injury (ATDILI) at least once. 3. Patients who have developed Antituberculosis drugs-induced liver injury (ATDILI), defined as having levels of Alanine aminotransferase (ALT) or Aspartate aminotransferase (AST) greater than three times the upper normal limit, along with jaundice (yellowing of the skin and eyes) and/or symptoms of hepatitis, such as abdominal pain, nausea, vomiting, or unexplained fatigue., or patients who have ALT or AST levels more than five times the upper normal limit, or a total bilirubin level greater than 3 mg/dl, in the absence of hepatitis symptoms and no other explanatory causes.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of adverse drug reactions to antituberculosis drugs. 2. Patients who have changed or discontinued antituberculosis drugs for reasons other than ATDILI. 3. Patients with pre-existing liver function abnormalities that meet the diagnostic criteria for ATDILI before starting antituberculosis treatment. 4. Patients who have discontinued treatment. 5. Pregnant patients or patients who are pregnant during tuberculosis treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk factors such as underweighted, obesity, NCD, HIV, previous tuberculosis, extra-pulmonary tuberculosis, anti-tuberculosis drug overdose, hypoalbuminemia 6 months Odd ratio | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactNattapat TANGAPIKIET
Banglamung hospital
Outcome results
None listed