Comparison effect of metformin on endometrial gene expression in polycystic ovary syndrome women with and without impaired glucose tolerance test: In vitro studies

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20250219008

Enrollment

Registered

2025-02-19

Start date

2024-01-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PCOS to a myriad of co-morbidities, including endometrial cancer, obesity, type 2 diabetes (T2D), depression, anxiety, nonalcoholic fatty liver disease, sleep apnea, and eating disorders. pcos metformin impaired glucose tolerance

Interventions

Endometrial sampling and Treatment with metformin 5 mM and 10 mM Analysis of gene expression by RT PCR,Endometrial sampling and Treatment with metformin 5 mM and 10 mM Analysis of gene expression by R

Basic Science,Basic Science

PCOS with impair glucose tolerance test,PCOS without impair glucose tolerance test

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Diagnosis of PCOS( International Evidence-based Guideline, 2023 ) with or without IGT ( 75 gm OGTT) 1.Age 18-45 years 2.BMI below 25 kg/m2 3.Abnormal uterine bleeding 4.No any hormonal treatment or metformin within 3 months 5.Negative UPT testing

Exclusion criteria

Exclusion criteria: 1.History of endometrial hyperplasia or endometrial carcinoma 2.Cervical lesion or pathology: cervical stenosis, cervical dysplasia, CIN, cervical cancer 3.Cannot obtain endometrial tissue by endometrial sampling devices 4.Patients who have bleeding tendency or use anti-coagulants or antiplatelet

Design outcomes

Primary

Measure	Time frame
To compare the effect of metformin on endometrial cancer related gene expression between Polycystic ovarian syndrome with or without Impair glucose tolerance test 12 months gene expression	—

Secondary

Measure	Time frame
To effect of metformin on endometrial cancer related gene in PCOS 12 MONTH GENE EXPRESSION	—

Countries

Thailand

Contacts

Public ContactPanisara Saekim

Siriraj Hospital

paniss2531@gmail.com66875803220

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026