End-staged knee osteoarthritis Total Knee Arthroplasty (TKA) Antibiotic Bone Cement (ABC) Inflammatory Response Interleukin-6 (IL-6) C-Reactive Protein (CRP)
Conditions
Interventions
use antibiotic-loaded bone cement in TKA,use non-antibiotic bone cement in TKA
Active Comparator Drug,Active Comparator Drug
antibiotic-loaded bone cement group,non-antibiotic bone cement group
Sponsors
Navamindradhiraj University Research Fund
Eligibility
Sex/Gender
Male
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 55-75 years diagnosed with Kellgren and Lawrence grade 3-4 KL3-4 knee osteoarthritis. 2. Patients who had failed conservative treatment. 3. Patients undergoing primary TKA for the affected knee. 4. Patients undergoing cemented TKA technique.
Exclusion criteria
Exclusion criteria: 1. Patients with knee osteoarthritis due to inflammatory joint diseases such as gout, pseudo-gout, rheumatoid arthritis, or spondyloarthropathy. 2. Presence of infection or suspected infection in the affected knee or a history of septic arthritis. 3. History of any previous knee surgery on the affected knee or procedures that could impact knee function. 4. Suspected immune deficiency, chronic liver disease, or use of immunosuppressive drugs. 5. History of gentamicin allergy. 6. Patients unable to ambulate postoperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory marker 3 days, 14 days postoperative Serum IL-6, Serum CRP, Serum ESR, Joint IL-6, Joint CRP | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee clinical outcome 14 days postoperative KOOS,Complication 14 days postoperative SSI, PJI | — |
Countries
Thailand
Contacts
Public ContactPruk Chaiyakit
Faculty of Medicine, Vajira Hospital, Navamindradhiraj University
Outcome results
None listed