Cystocele Cystocele
Conditions
Interventions
Participants undergo cystocele repair (anterior colporrhaphy) without any additional PRP injection. The pubocervical fascia is sutured using PGA sutures after the standard surgical procedure.,Particip
Experimental Procedure/Surgery,Experimental Procedure/Surgery
Control Group : anterior colporrhaphy alone,Intervention Group
Sponsors
Faculty of Medicine, Universitas Riau
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Menopausal women diagnosed with grade 3 or 4 cystocele (POP-Q) who provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with platelet disorders or severe thrombocytopenia 2. NSAID use within 48 hours prior to intervention 3. Corticosteroid use in the past month 4. Prior POP surgery 5. Inability/unwillingness to comply with study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in Pelvic Organ Prolapse Quantification (POP-Q) Stage Day 90 postoperatively POP-Q assessment performed by a trained clinician. Improvement is defined as a reduction in POP-Q stage compared to baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in Urinary Distress Inventory (UDI-6) Score Day 28 and Day 90 postoperatively Change in UDI-6 score measured using a validated questionnaire. Lower scores indicate improvement in urinary symptoms.,Reduction in Pelvic Floor Distress Inventory (PFDI-20) Score Day 28 and Day 90 postoperatively Change in PFDI-20 score measured using a validated questionnaire. Lower scores indicate improvement in pelvic floor symptoms.,Improvement in Quality of Life (QoL) Score Day 28 and Day 90 postoperatively Change in QoL score assessed using a validated quality of life instrument specific to pelvic floor disorders. Higher scores indicate better quality of life.,Platelet-Derived Growth Factor (PDGF) Levels Preoperative (Day 0) and Day 3 postoperatively Serum levels of PDGF measured via laboratory analysis to assess PRP-related growth factor activity. | — |
Countries
Indonesia
Contacts
Public ContactEdy Fakhrizal
Fakultas Kedokteran Universitas Riau
Outcome results
None listed