Melasma Melasma, 2% hydroquinone cream, topical treatment
Conditions
Interventions
The patients'
faces were randomly assigned, with one side treated using Alpha Bright serum and the other side treated with 2% hydroquinone cream. They were then instructed to follow up at 1, 2, and 3 months during
Active Comparator Drug,Active Comparator Drug
Alpha bright serum ,2% hydroquinone cream
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
35 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. aged 35-55 years 2. were diagnosed with epidermal or mixed type melasma by physical examination and wood's lamp 3. Thais
Exclusion criteria
Exclusion criteria: 1. Patients who are pregnant or lactating 2. Patients with dermatitis, open wound, or having infection at the area of face 3. Patients who received hormonal treatment or contraceptive pills/injection within 3 months 4. Patients who received topical or oral melasma treatment within 3 months 5. Patients who underwent facial laser treatment within 3 months 6. Patients with mental disorders 7. Patients who do not allow photography 8. Patients who allergic to topical vitamin C, essential Fraction of Ginkgo biloba and Phytic acid 9. Patients with history of hydroquinone and sunscreen allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average melanin concentration by Antera Baseline, 1, 2, 3 months during the treatment and 1, 2, 3 months after the treatment Antera,Melanin index Baseline, 1, 2, 3 months during the treatment and 1, 2, 3 months after the treatment Mexameter,Erythema index Baseline, 1, 2, 3 months during the treatment and 1, 2, 3 months after the treatment Mexameter | — |
Secondary
| Measure | Time frame |
|---|---|
| Physician improvement scale 1, 2, 3 months during the treatment and 1, 2, 3 months after the treatment Quartile scale,modified Melasma Area Severity Index score Baseline, 1, 2, 3 months during the treatment and 1, 2, 3 months after the treatment modified Melasma Area Severity Index score,Patient improvement scale 1, 2, 3 months during the treatment and 1, 2, 3 months after the treatment Quartile scale | — |
Countries
Thailand
Contacts
Public ContactRungsima Wanitphakdeedecha
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed