Postoperative delirium in elderly patients who undergo elective surgery under GA and are admitted to the ICU postoperatively. sevoflurane, desflurane, postoperative delirium, intensive care unit, elderly
Conditions
Interventions
General anesthesia is maintained with 1 MAC of sevoflurane (age-adjusted) in an air-oxygen mixture.,General anesthesia is maintained with 1 MAC of desflurane (age-adjusted) in an air-oxygen mixture.
Experimental Drug,Active Comparator Drug
Sevoflurane group,Desflurane group
Sponsors
KHON KAEN UNIVERSITY
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age of 65 years or more 2. Predicted to be admitted postoperatively to the surgical ICU
Exclusion criteria
Exclusion criteria: 1. Cardiothoracic surgery and neurosurgery 2. Contraindications to sevoflurane or desflurane 3. Preferable indication to sevoflurane or desflurane 4. Contraindications for the following medications; fentanyl, propofol, succinylcholine, cisatracurium, dexamethasone and ondansetron. 5. Preexisting neurological or psychiatric conditions 6. Patients with limitations of Thai CAM-ICU evaluation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium 48 hours after the intervention Thai version of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of ICU stay Any time after the intervention Chart and medical record review,Length of hospital stay Any time after the intervention Chart and medical record review,Duration of mechanical ventilation Any time after the intervention Chart and medical record review,Hospital mortality Any time after the intervention Chart and medical record review,28-day mortality 28 days after the intervention Medical record review or telephone interview | — |
Countries
Thailand
Contacts
Public ContactPasit Surakamhaeng
Department of Anesthesiology, Faculty of Medicine, Khon Kaen University
Outcome results
None listed