Autism Spectrum Disorder Autism Spectrum Disorder, Irritability, Serotonin, Risperidone, Aripiprazole
Conditions
Interventions
patients who met the inclusion criteria and received Risperidone therapy at a dose of 0.02-0.06 mg/ kgBW/ day.,patients who meet the inclusion criteria and receive Aripiprazole therapy with an initial
Experimental Drug,Active Comparator Drug
Treatment Group,control Grup
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
5 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with ASD according to DSM-5. 2. Patients aged 5 to 17 years. 3. Receiving Risperidone therapy with a dosage range of 0.02 to 0.06 mg/kg/day. 4. Receiving Aripiprazole therapy with an initial dose of 0.3 to 0.6 mg/kg/day. 5. Not using any antipsychotic agents other than Risperidone and Aripiprazole prior to the study. 6. ABC-I score more than 18. 7. Parents agree to sign the informed consent form and comply with the testing requirements.
Exclusion criteria
Exclusion criteria: Subjects were excluded from the study if they had other physical illnesses (cardiovascular, endocrine and metabolic, immunosufficiency, and infections), and/or had comorbid psychiatric illnesses (schizophrenia, psychotic disorders, and epilepsy).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| THE COMPARISON EFFECTS OF RISPERIDONE AND ARIPIPRAZOLE ON IRRITABILITY SYMPTOMS AND SEROTONIN LEVELS IN CHILDREN WITH AUTISM SPECTRUM DISORDER at baseline, week 4, and week 8 of therapy. Numeric was evaluated using the Aberrant Behavior Checklist - Irritability (ABC-I) score | — |
Secondary
| Measure | Time frame |
|---|---|
| IRRITABILITY SYMPTOMS at baseline, week 4, and week 8 of therapy. Numeric was evaluated using the Aberrant Behavior Checklist - Irritability (ABC-I) score | — |
Countries
Indonesia
Contacts
Public ContactRohmatyah Suaib
Faculty of Medicine Hasanuddin University
Outcome results
None listed