The Effects of Dual-mode Brain Stimulation on Upper Limb Functions in Individuals with Subacute Stroke: A Randomized Controlled Trial

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250215001

Enrollment

Registered

2025-02-15

Start date

2025-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Weakness on the upper limb function in individuals with subacute stroke Dual-mode brain stimulation, upper limb function, transcranial magnetic stimulation, Transcranial direct current stimulation/ Subacute stroke

Interventions

Dual-mode brain stimulation works on both hemispheres in subacute stroke patients.,Single-mode brain stimulation works on the lesioned hemispheres in subacute stroke patients.,AOE works on the paretic

Experimental Device,Active Comparator Device,Active Comparator Behavioral

Dual-mode brain stimulation,Single-mode brain stimulation ,Action Observation Execution (AOE) training

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Aged between 40-80 years; 2) First-ever subcortical ischemic or hemorrhagic stroke of the MCA within 1 to 6 months ; 3) Right-handedness ; 4)Mini-mental state examination scores (MMSE more than 23/30); 5) Independent sitting for at least an hour; 6) Able to reach-to-grasp at least once; 7) Able to communicate and follow the instructions

Exclusion criteria

Exclusion criteria: 1) Other diseases affecting on upper limb function (other neurological problems such as brain tumours and brain injury, and other musculoskeletal problems); 2) Contraindications of TMS and tDCS; 3) Pain during RTG ; 4) Visual disorders limiting the ability ; 5) Global aphasia; 6) Ideomotor apraxia; 7) Received tricyclic anti-depressants, neuroleptic agents, and other drugs that affected decreased seizure threshold; 8) History of receiving non-invasive brain stimulation within the washout period

Design outcomes

Primary

Measure	Time frame
Corticospinal excitability at baseline, intermediate, and follow-up 1 and 2 weeks after intervention Transcranial magnetic stimulation,kinematic reach-to-grasp movement at baseline, intermediate, and follow-up 1 and 2 weeks after intervention MotionMonitor system	—

Secondary

Measure	Time frame
Quality of life at baseline, intermediate, and follow-up 1 and 2 weeks after intervention Stroke impact scale (SIS)	—

Countries

Thailand

Contacts

Public ContactSupattra Chaibal

Faculty of Physical Therapy, Mahidol University

supattra.ch@mail.wu.ac.th0841702546

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026