Currently, various injectable treatments are available for knee osteoarthritis. However, at Songklanagarind Hospital, only HA injections are available. Therefore, understanding the effectiveness of other injectable treatments compared to HA is essential. If this study demonstrates that PN-based injections provide comparable or superior therapeutic outcomes to HA, including PN in the hospital'
Conditions
Interventions
OSTENIL is an isotonic solution of highly purified hyaluronan (sodium hyaluronate) specifically developed for the treatment of osteoarthritis. It contains 20 mg/2 ml of sodium hyaluronate and is admin
Active Comparator Drug,Experimental Drug
Ostenil,Conjuran
Sponsors
Prince of Songkla University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 40 years or older, 2.Diagnosed with knee osteoarthritis (OA) with a severity level of I-III based on the Kellgren-Lawrence (KL) classification, assessed using standard standing knee X-rays before study enrollment, 3. Experiencing knee pain from OA that has not responded to at least 3 months of initial treatment, such as medication or physical therapy, 4. Knee pain severity score of at least 40 out of 100 on the Visual Analogue Scale (VAS), 5. Able to understand and complete questionnaires.
Exclusion criteria
Exclusion criteria: 1. Complete loss of knee joint space on X-ray or knee osteoarthritis classified as KL grade IV, 2. History of severe knee injury or previous knee surgery, 3. History of infection, rheumatoid arthritis, or other inflammatory joint diseases, 4. Received intra-articular knee injections within the past 3 months, 5. Underwent physical therapy, acupuncture, massage, or shockwave therapy for knee pain within the past 2 weeks, 6. History of allergy to intra-articular injection medications, 7. Blood coagulation disorders or use of anticoagulants and/or antiplatelet medications within the past week, 8. Skin lesions or dermatological conditions around the knee, such as psoriasis or eczema
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain scores 6 weeks visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| functional outcome 6 weeks The Knee injury and Osteoarthritis Outcome Score (KOOS),functional outcome 6 weeks The Knee Society Score (KSS),functional outcome 6 weeks The EuroQol Visual Analogue Scale (EQ-VAS),patient satisfaction 6 weeks Numeric Rating Scale,complications 6 weeks Incidence rate | — |
Countries
Thailand
Contacts
Public ContactChirathit Anusitviwat
Faculty of Medicine, Prince of Songkla University
Outcome results
None listed