knee osteoarthritis platelet-rich plasma, PRP, knee OA, corticosteroids
Conditions
Interventions
Receiving 5 ml of intra-articular platelet-rich plasma (PRP3) injections three times, at three weeks apart.,Receiving a single 5 ml intra-articular PRP injection ,Receiving a single 40 mg intra-articu
Experimental Drug,Experimental Drug,Experimental Drug
3 intra-articular platelet-rich plasma (PRP3) group ,single intra-articular PRP injection (PRP1) group,intra-articular triamcinolone 40 mg (TA) injection group
Sponsors
Ratchadapisek pageant research Fund
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Primary knee osteoarthritis with symptoms Aged over 18 years old Advanced knee osteoarthritis (KL grade 3,4) BMI less than 30 kg/m2 normal CBC
Exclusion criteria
Exclusion criteria: Inflammatory joint diseases Concomitant hip or ankle OA Previous knee surgery Hematologic disorders Use anticoagulant for medication Systemic or local knee infection Any IA injection within last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score 3, 6, 12 week visual analog scale(VAS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee function 3,6,12 weeks The Western Ontario and McMaster Universities Arthritis Index (WOMAC) score, Performanced score 3,6,12 week 3-minuted walk test (3MWT), 5-times sit to stand score (5xSST), Time up and go score (TUG) | — |
Countries
Thailand
Contacts
Public ContactWorawich Kraipindakil
Chulalongkorn hospital
Outcome results
None listed