Patient with chonic liver disease who suffered with pruritus for more than 2 weeks with out known underlying specific skin disease such as atopic dermatitis, psoriasis, dermatophytosis, candidiasis, or other active skin infection. Pruritius, chronic liver disease, cirrhosis, Andrographis paniculata, Herbal medicine
Conditions
Interventions
Participants underwent a computer generated 1:1 block randomization to receive either a 4% Andrographis paniculata extract cream (supplied by SBU Corporation) or a placebo moisturizing cream. Applicat
Experimental Drug,Placebo Comparator Drug
tropical Andrographis paniculata extract group,Placebo ( moisterizing cream)
Sponsors
Chiang Rai Prachanukroh hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The inclusion criteria for participants required 1. Individuals to be 18 years of age or older 2. Diagnosed with chronic liver disease or cholestatic liver disease 3. Presented with generalized pruritus persisting for more than 2 weeks.
Exclusion criteria
Exclusion criteria: The exclusion criteria included: 1. Allergy to Andrographis paniculata. 2. Use of topical steroids within the past 2 weeks. 3. Impaired consciousness due to specific conditions. 4. A life expectancy of less than 4 weeks. 5. Pregnancy or breastfeeding. 6. Blood pressure below 90/60 mmHg. 7. Low platelet counts or abnormal blood clotting. 8. Known underlying skin diseases such as atopic dermatitis, psoriasis, dermatophytosis, candidiasis, or other chronic skin infections
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pruritus 4 weeks Dynamic pruritus score | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life 4 week Dermatology Life Quality Index( DLQI) | — |
Countries
Thailand
Contacts
Public ContactChotipong Siripipattanamongkol
Chiang Rai Prachanukroh hospital
Outcome results
None listed