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Proportional assist ventilation versus pressure support ventilation to reduce respiratory effort parameters in the weaning of patients with respiratory failure: A Randomized cross-over study

Proportional assist ventilation versus pressure support ventilation to reduce respiratory effort parameters in the weaning of patients with respiratory failure: A Randomized cross-over study

Status
Unknown
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250206005
Enrollment
174
Registered
2025-02-06
Start date
2024-03-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

on ventilator in PAV+ mode for 30 minutes and then record hemodynamic and respiratory parameters for 15 minutes,on a ventilator in PSV mode for 30 minutes and then record hemodynamic and respiratory p
Active Comparator Device,Active Comparator Device
PAV+,PSV

Sponsors

no
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age > 18 years 2.Received treatment at the medical ICU or intermediate ward (7NW, 8IK, and 9IC) 3. Under mechanical ventilator for at least 48 hours 4 .Received a ventilator with PAV+ mode (Puritan-Bennett 980 ventilator (Nellcor Puritan Bennett LLC, Gosport, UK Gosport, UK) 5. The patient is ready to wean off the ventilator -The patient is capable of initiating an inspiratory effort and has a normal level of consciousness -Uses a fraction of inspired oxygen less than 0.4 (FiO2 < 0.4) PEEP <= 8 cm H2O -No excessive tracheal secretions (requires more than normal sputum suction) -The patient or relatives consent to participate in the research project.

Exclusion criteria

Exclusion criteria: 1. Patients with unstable vital signs: 2. Mean blood pressure < 65 mmHg 3.Unstable arrhythmia (HR>150 or < 40 bpm) 4 .Patients with oxygen saturation < 90% 5. Patients with neurological abnormalities that affect breathing 6 . Patients treated with supportive care 7 . Patients who have a tracheostomy tube 8 .Patient on PSV mode with pressure support <= 5 cmH2O and awaiting extubation 9. Patients or relatives refuse to participate in research or request to withdraw from the research

Design outcomes

Primary

MeasureTime frame
Respiratory parameters at 30 mins after adjust ventilator Ventilatory measurement

Secondary

MeasureTime frame
Asynchrony at 30 mins after adjust ventilator Asynchrony index

Countries

Thailand

Contacts

Public ContactYuda Sutherasan

Pulmonary and Critical Care Medicine

sutherasan_yuda@yahoo.com022011619

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026