Elderly statin use Elderly dyslipidemia Exrcise program statins resistance training
Conditions
Interventions
Continue their prescribed statin medication as directed by their physician.
Refrain from engaging in any additional exercise or physical activity programs outside of their usual daily activities.
,The
No Intervention No treatment,Experimental Other,Active Comparator Other
Statin control,Statin PRE,No Statin PRE
Sponsors
Faculty of Allied Health Sciences Burapha University (Revenue Budget)
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Volunteers Using Statins 1. Male or female, aged 60 years and above. 2. Body mass index (BMI) greater than 15 kg/m2. 3. Able to perform lower limb movement or exercise. 4. Continuous use of statins for at least one year prior to the study (participants must provide their own statin medication records or obtain this information from the healthcare facility they visit). 5. No regular resistance or aerobic exercise (defined as engaging in such exercise for at least two days per week) in the six months preceding the study. 6. No history of diagnosed heart disease, neurological disorders, or chronic respiratory diseases (e.g., chronic pneumonia, emphysema). 7. No history of patellar fractures. Volunteers Not Using Statins 1. Male or female, aged 60 years and above. 2. Body mass index (BMI) greater than 15 kg/m2. 3. Able to perform lower limb movement or exercise. 4. No use of statins for at least one year prior to the study. 5. No regular resistance or aerobic exercise (defined as engaging in such exercise for at least two days per week) in the six months preceding the study. 6. No history of diagnosed heart disease, neurological disorders, or chronic respiratory diseases (e.g., chronic pneumonia, emphysema). 7. No history of patellar fractures.
Exclusion criteria
Exclusion criteria: 1. Currently has uncontrolled hypertension. 2. History of diagnosed heart disease, neurological disorders, or chronic respiratory diseases (e.g., chronic pneumonia, emphysema). 3. Currently experiencing active inflammatory arthritis. 4. History of quadriceps tendon rupture. 5. Received corticosteroid injections in the quadriceps muscle or patellar tendon within one year prior to the study. 6. Long-term corticosteroid use for more than one month. 7. Currently participating in a muscle-strengthening exercise program. 8. Currently taking medications or supplements that affect training-induced muscle adaptations. 9. Lower limb abnormalities, disabilities, or joint contractures that prevent participation in the prescribed resistance exercise program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lower limbs muscle strength before and after 8-week program Biodex system 4,functional ability before and after 8-week program TUG, FRT,Serum biomarker before and after 8-week program CRP, CPK, CBC,lipid profile before and after 8-week program HDL, LDL, Triglyceride, Choresterol,QOL before and after 8-week program WHOQOL | — |
Secondary
| Measure | Time frame |
|---|---|
| lower limbs muscle morphology before and after 8-week program real time US imaging,functional ability before and after 8-week program 10MWT, 4SSCT,cardiorespiratory fitness before and after 8-week program spirometer, MIP, 6MWT,Physical activity before and after 8-week program GPAQ,cognitive function before and after 8-week program Trail Making Tests (TMT), Stoop test program, digit span test,serum and plasma marker before and after 8-week program oxidative stress, antioxydant, BDNF | — |
Countries
Thailand
Contacts
Public ContactSIRIRAT KIATKULANUSORN
Burapha University, Thailand
Outcome results
None listed