Efficacy of low dose oral Isotretinoin combination with fractional radiofrequency microneedling in moderate to severe acne vulgaris Low dose isotretinoin, Radiofrequency microneedling, Acne vulgaris
Conditions
Interventions
Fractional Radiofrequency Microneedling is a novel radiofrequency technique that deliver energy to controllable depth of the skin.The intervention provides microtrauma to cutaneous tissues and generat
Fractional Radiofrequency Microneedling and low dose isotretinoin,low dose isotretinoin
Sponsors
Thammasat University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Males and females aged between 18 and 50 years old, specifically those diagnosed with moderate to severe Acne Vulgaris according to the Global Acne Grading System, were included in the study. 2. Women who are menstruating must be advised on contraceptive measures and use contraceptive methods such as condoms or intrauterine devices
Exclusion criteria
Exclusion criteria: 1. Individuals with underlying skin conditions, such as atopic dermatitis, psoriasis, vitiligo, or other underlying diseases that may cause skin abnormalities, such as diabetes mellitus, chronic renal failure, cirrhosis, or porphyria. 2. Individuals who are pregnant, planning to become pregnant, or breastfeeding. 3. Individuals with underlying diseases related to immune system dysfunction, such as primary immunodeficiencies, HIV, anaphylaxis, asthma, generalized drug reactions, lymphoma, leukemia, rheumatoid arthritis, or systemic lupus erythematosus. 4. Individuals with underlying conditions, including hyperlipidemia, liver disease, kidney disease, malnutrition, or polycystic ovary syndrome (PCOS). 5. Individuals who have previously undergone treatments with 1,450-nm diode laser, 595-nm pulsed dye laser, intense pulsed light photodynamic therapy, non-ablative erbium glass fractional laser, or ablative 10,600-nm carbon dioxide fractional laser within the 6 months prior to starting the study. 6. Individuals with a history of keloids or a tendency to develop keloids easily. 7. Individuals who have used isotretinoin or combined hormonal contraceptives within the last 6 months. 8. Individuals who have stopped using steroids less than 3 months before starting the study. 9. Individuals who have stopped using acne treatment medications, oral antibiotics, or topical acne medications less than 4 weeks before starting the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acne count 0,12,20,24,32,44 week Global Acne Grading score | — |
Secondary
| Measure | Time frame |
|---|---|
| Texture, Hemoglobin 0,12,20,24,32,44 week Antera 3D | — |
Countries
Thailand
Contacts
Public ContactWareeporn Disphanurat
Thammasat University Hospital
Outcome results
None listed