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Benefits of three consecutive sputum inductions using nebulized racemic salbutamol versus hypertonic saline in smear-negative or sputum-scarce pulmonary tuberculosis patients: A prospective randomized, double-blind study

Benefits of three consecutive sputum inductions using nebulized racemic salbutamol versus hypertonic saline in smear-negative or sputum-scarce pulmonary tuberculosis patients: A prospective randomized, double-blind study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250201002
Enrollment
128
Registered
2025-02-01
Start date
2016-11-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

smear-negative or sputum-scarce pulmonary tuberculosis smear negative, pulmonary tuberculosis

Interventions

sputum induction by nebulized salbutamol for diagnosis pulmonary tuberculosis,sputum induction by 3 % Nacl solution for diagnosis pulmonary tuberculosis
Active Comparator Drug,Active Comparator Drug
sputum induction by nebulized salbutamol solution,sputum induction by 3 % Nacl solution

Sponsors

Prince of Songkla University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Patients at least 18 years of age, who were suspected of having PTB (2) Negative AFB smears on 3 consecutive days of self-expectorated sputum or being sputum-scarce.

Exclusion criteria

Exclusion criteria: 1. Patients diagnosed with asthma, COPD, uncontrolled hypertension, cardiac arrhythmias, unstable medical conditions, pregnancy 2. History of beta-agonist hypersensitivity 3. Having had received anti-tuberculosis drugs within the previous 2 months 4. Having had a positive AFB smear from self-expectoration, or proven another diagnosed causes of chest symptoms and abnormal imaging

Design outcomes

Primary

MeasureTime frame
efficacy 2 weeks diagnosis tuberculosis

Secondary

MeasureTime frame
satey of sputum induction 2 weeks side effect

Countries

Thailand

Contacts

Public Contactwarangkana keeratichananont

Prince of Songkla University

tikrittirak@gmail.com0815980987

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026