Non-insulated microneedle radiofrequency for the treatment of hydroquinone-induced exogenous ochronosis: A case report and literature review

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20250126002

Enrollment

Registered

2025-01-26

Start date

2024-08-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exogenous ochronosis Energy-based device, deposition disease, hyperpigment,melasma, ochronosis, laser, radiofrequency therapy, MNRF

Interventions

Non-insulated microneedle bipolar radiofrequency (Sylfirm X plus, Viol Corporation , South Korea) was used to treat the affected areas for 3 sessions with continuous-wave mode ,depth 2 millimeters ,

Experimental Device

Non-insulated microneedle radiofrequency

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: In this case report only a single patient diagnosed with exogenous ochronosis was included.

Exclusion criteria

Exclusion criteria: no

Design outcomes

Primary

Measure	Time frame
Lightening of lesion at 1 month after end of intervention physician assessment	—

Secondary

Measure	Time frame
decrease of ochronotic pigment at 1 month after end of intervention dermatoscopic assessment	—

Countries

Thailand

Contacts

Public ContactNatthachat Jurairattanaporn

Department of Medicine, Ramathibodi hospital , Mahidol university

natthachat.j.md@gmail.com66944651415

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026